Epigenetic codes in cognition and behaviour.
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23 citations
Cites background from "Epigenetic codes in cognition and b..."
...The inheritance of numerous genetic risk factors for human and plant diseases as well as biotic and abiotic stress susceptibility phenotypes are well established [16]....
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...The influences of age and environment (for example, chemicals, heat, nutrition, daylight) on various pathologies and the seemingly stochastic penetrance of developmental abnormalities are particularly difficult to interpret using purely molecular genetic models and are more easily explained by considering epigenetic control mechanisms [13-18]....
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22 citations
Cites background from "Epigenetic codes in cognition and b..."
...In addition, a defective histone PTM profile in nerve cells has been observed in neurodevelopmental, neurodegenerative and neuropsychiatric disorders [4,44]....
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...Histone PTMs also contribute to complex brain functions such as learning and memory, and together with other epigenetic mechanisms such as DNA methylation, they play a fundamental role in these processes [4, 16, 25]....
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...Dysregulation of the epigenetic profile of nerve cells can be detrimental, and has been associated with neurodevelopmental, neurodegenerative and neuropsychiatric disorders [4]....
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22 citations
22 citations
22 citations
Cites result from "Epigenetic codes in cognition and b..."
...Moreover, as differences in the transcription level of genes related to cognitive function had already been detected among similar groups of fishes [11], and their long-term persistence was recently shown [10], we additionally measured the transcription level of four genes related to long lasting regulation of cognitive function [13,14] and compared it to experimentally measured climbing behaviour....
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References
11,123 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...These forms f plasticity reflect respectively, an increase and a decrease in he efficiency of synaptic transmission, and have been extenively studied in the hippocampus, a brain area required for earning and memory (for a review see [30])....
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10,046 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...Chronic xposure to an aggressor results in pronounced social avoidnce, prolonged downregulation of two splice variants of Bdnf, dnfIII and BdnfIV in the hippocampus and increased promoter imethylation of H3K27 [102], a mark of transcriptional represion [20]....
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9,309 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...These nzymes operate both independently and in synergy to establish “histone code”, a highly dynamic and flexible chromatin markng that, in combination with chromatin-associated proteins, etermines the pattern of gene expression in response to given xternal stimuli [24,25]....
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6,691 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...ecause of the covalent nature of the binding of methyl groups o the C5 carbon in cytosine, DNA methylation is thought to be he most stable epigenetic mark [9]....
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...DNA methylation is commonly associated with ranscriptional silencing because it can directly inhibit the bindng of transcription factors or regulators, or indirectly recruit ethyl-CpG binding proteins (MBPs), which have repressive hromatin-remodeling functions [9,10]....
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...Most cases of RS are caused by mutaions in the gene coding for methyl-CpG binding protein 2 MeCP2) [62], a member of the MBP family involved in ong-term gene silencing (for a review see [9])....
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5,760 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...ot be explained by changes in the DNA sequence itself [3] reviewed in [4,5])....
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