Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
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TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
Citations
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Journal ArticleDOI
Human-specific hypomethylation of CENPJ, a key brain size regulator.
TL;DR: The hypomethylation and comparatively high expression of CENPJ in the central nervous system of humans suggest that a human-specific--and likely heritable--epigenetic modification likely occurred during human evolution, potentially leading to a much larger neural progenitor pool during human brain development, which may have eventually contributed to the dramatically enlarged brain and highly developed cognitive abilities associated with humans.
Royaume du maroc
TL;DR: Theoretique de l’optique géométrique : rayon lumineux 2.1.1 Approximation des régimes quasi-permanents 4.2 Éléments de circuits linéaires en régime continu ou quasi-Permanent 4.3 Régime transitoire 4.5 Filtrage linéaire 4.6 Amplificateur opérationnel.
Journal ArticleDOI
Genome-wide DNA methylation in suicide victims revealing impact on gene expression.
TL;DR: A preliminary methylation study with single base pair resolution using NGS on one of the world populations with a very high suicide risk offering novel insights into altered methylation patterns in suicide victims could provide a starting point for further studies on clinical samples with highly expressed suicide risk.
Book ChapterDOI
Behavioral Genetics and Animal Domestication
Per Jensen,Dominic Wright +1 more
TL;DR: In this chapter, domestication is defined as a genetic process, whereby animals change phenotypically and genetically as a response to living under human supervision, through a combination of relaxed natural selection, increased human selection, and correlated responses.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
Journal ArticleDOI
Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
Journal ArticleDOI
DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
Journal ArticleDOI
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.