Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
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TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
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Alteration of epigenetic program to recover memory and alleviate neurodegeneration: prospects of multi-target molecules
Ganesh N. Pandian,Rhys Dylan Taylor,Syed Junetha,Abhijit Saha,Chandran Anandhakumar,Thangavel Vaijayanthi,Hiroshi Sugiyama +6 more
TL;DR: A balanced overview of the key factors associated with memory recovery and neurodegeneration, available chemical tools for modulation and the demand to develop next-generation small molecules with multi-functional activities to treat such intricate, multi-gene associated neurological disorders are given.
Journal ArticleDOI
DNA methylation variation in the brain of laying hens in relation to differential behavioral patterns
Carlos Guerrero-Bosagna,Fábio Pértille,Yamenah Gómez,Shiva Rezaei,Sabine G. Gebhardt-Henrich,Sabine Vögeli,Ariane Stratmann,Bernhard Voelkl,Michael J. Toscano +8 more
TL;DR: This study suggests that different biological functions within neurons (particularly in the nidopallium) could be responsible for the emergence of distinct behavior patterns and that epigenetic variation within brain tissues would be an important factor to explain behavioral variation.
Journal ArticleDOI
An Evaluation of DNA Methyltransferase 1 (DNMT1) Single Nucleotide Polymorphisms and Chemotherapy-Associated Cognitive Impairment: A Prospective, Longitudinal Study.
Alexandre Chan,Angie Yeo,Maung Shwe,Chia Jie Tan,Koon Mian Foo,Pat Chu,Chiea Chuen Khor,Han Kiat Ho +7 more
TL;DR: The first study to show a significant association between a DNMT1 rs2162560 polymorphism and chemotherapy-associated cognitive impairment (CACI) in a cohort of breast cancer patients is shown.
Journal ArticleDOI
Differential Histone Acetylation in Sub-Regions of Bed Nucleus of the Stria Terminalis Underlies Fear Consolidation and Extinction.
Vandana Ranjan,Sanjay Singh,Sarfraj Ahmad Siddiqui,Sukanya Tripathi,M. Y. Khan,Anand Prakash +5 more
TL;DR: The results from this study suggest that the differential histone acetylation in the different sub-regions of the BNST following fear learning and its extinction may be responsible for changes in the neuronal activation patterns resulting in either fear or less fear.
Journal ArticleDOI
Gene Network Construction from Microarray Data Identifies a Key Network Module and Several Candidate Hub Genes in Age-Associated Spatial Learning Impairment.
Raihan K. Uddin,Shiva M. Singh +1 more
TL;DR: A mathematical modeling approach implemented in Weighted Gene Co-expression Network Analysis (WGCNA) is used to create and compare gene network models of young and aged brains from a set of exploratory datasets in rats in the context of ASLI, and identify novel ASLI related genes and their networks based on co-expression relationship of genes.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
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Chromatin Modifications and Their Function
TL;DR: The surface of nucleosomes is studded with a multiplicity of modifications that can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA.
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Translating the Histone Code
Thomas Jenuwein,C. David Allis +1 more
TL;DR: It is proposed that this epigenetic marking system represents a fundamental regulatory mechanism that has an impact on most, if not all, chromatin-templated processes, with far-reaching consequences for cell fate decisions and both normal and pathological development.
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DNA methylation patterns and epigenetic memory
TL;DR: The heritability of methylation states and the secondary nature of the decision to invite or exclude methylation support the idea that DNA methylation is adapted for a specific cellular memory function in development.
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.