Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
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TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
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Socioeconomic status and the developing brain
TL;DR: These studies indicate that SES is an important predictor of neurocognitive performance, particularly of language and executive function, and that S ES differences are found in neural processing even when performance levels are equal.
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Lasting epigenetic influence of early-life adversity on the BDNF gene.
TL;DR: An epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect is highlighted.
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Transcription Factors in Long-Term Memory and Synaptic Plasticity
TL;DR: The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.
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Histone acetylation: molecular mnemonics on the chromatin
TL;DR: As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.
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Finding the engram.
TL;DR: This Review develops four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram, and proposes that findings from 'capture' studies represent considerable progress in allowing us to observe, erase and express the engrams.
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Journal ArticleDOI
Epigenetic mechanisms in memory formation
TL;DR: Neurobiologists have only recently begun to investigate the possible roles of epigenetic mechanisms in behaviour, physiology and neuropathology, and relevant data from the few extant neurobiology-related studies have already indicated a theme — epigenetic mechanism probably have an important role in synaptic plasticity and memory formation.
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Epigenetic gene silencing in cancer: the DNA hypermethylome
TL;DR: The importance of hypermethylation events is already in evidence at the bedside of cancer patients in the form of cancer detection markers and chemotherapy predictors, and in the approval of epigenetic drugs for the treatment of hematological malignancies, as well as in the synergy of candidate gene approaches and large-scale epigenomic technologies, such as methyl-DIP.
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Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice
Robert J. Ferrante,James K. Kubilus,Junghee Lee,Hoon Ryu,Ayshe Ana Beesen,Birgit Zucker,Karen L. Smith,Neil W. Kowall,Rajiv R. Ratan,Ruth Luthi-Carter,Steven M. Hersch +10 more
TL;DR: Findings strengthen the hypothesis that transcriptional dysfunction plays a role in the pathogenesis of HD and suggest that therapies aimed at modulating transcription may target early pathological events and provide clinical benefits to HD patients.
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Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs after maternal and paternal transmission
Vardhman K. Rakyan,Suyinn Chong,Marnie E. Champ,Peter C. Cuthbert,Hugh Morgan,Keith V. K. Luu,Emma Whitelaw +6 more
TL;DR: It is found that the methylation state of AxinFu in mature sperm reflects the methylated state of the allele in the somatic tissue of the animal, suggesting that it does not undergo epigenetic reprogramming during gametogenesis, and it is shown that epigenetic inheritance is influenced by strain background.
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Transgeneration memory of stress in plants
TL;DR: It is shown that in Arabidopsis thaliana plants treated with short-wavelength radiation or flagellin, somatic homologous recombination of a transgenic reporter is increased in the treated population and these increased levels of homologously recombination persist in the subsequent, untreated generations.