Journal ArticleDOI
Epigenetic codes in cognition and behaviour.
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TLDR
Recent findings on the role and mechanisms of epigenetic codes in the brain are described, and their implication in synaptic plasticity, cognitive functions and psychiatric disorders are discussed.About:
This article is published in Behavioural Brain Research.The article was published on 2008-09-01. It has received 260 citations till now. The article focuses on the topics: Epigenetic code & Epigenetics.read more
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Socioeconomic status and the developing brain
TL;DR: These studies indicate that SES is an important predictor of neurocognitive performance, particularly of language and executive function, and that S ES differences are found in neural processing even when performance levels are equal.
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Lasting epigenetic influence of early-life adversity on the BDNF gene.
TL;DR: An epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect is highlighted.
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Transcription Factors in Long-Term Memory and Synaptic Plasticity
TL;DR: The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation.
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Histone acetylation: molecular mnemonics on the chromatin
TL;DR: As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.
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Finding the engram.
TL;DR: This Review develops four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram, and proposes that findings from 'capture' studies represent considerable progress in allowing us to observe, erase and express the engrams.
References
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Journal ArticleDOI
Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear
TL;DR: A relationship between histone H4 modification, epigenetic regulation of BDNF gene expression, and long-term memory for extinction of conditioned fear is suggested and HDAC inhibitors may become a useful pharmacological adjunct to psychotherapy for human anxiety disorders.
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Transgenerational response to nutrition, early life circumstances and longevity
TL;DR: Investigating to what extent the probands own childhood circumstances are in fact the determinants of the findings finds that TGRs to ancestors' nutrition prevailed as the main influence on longevity.
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Endocrine Disruptor Vinclozolin Induced Epigenetic Transgenerational Adult-Onset Disease
TL;DR: The observations demonstrate that an environmental compound, endocrine disruptor, can induce transgenerational disease states or abnormalities, and this suggests a potential epigenetic etiology and molecular basis of adult onset disease.
Journal ArticleDOI
The Transcription Factor Nerve Growth Factor-Inducible Protein a Mediates Epigenetic Programming: Altering Epigenetic Marks by Immediate-Early Genes
Ian C. G. Weaver,Ana C. D'Alessio,Shelley E. Brown,Ian C. Hellstrom,Sergiy Dymov,Shakti Sharma,Moshe Szyf,Michael J. Meaney +7 more
TL;DR: Site-directed mutagenesis assays demonstrate that NGFI-A binding to the exon 17 GR promoter is required for epigenetic reprogramming of GR expression, and Knockdown experiments of NGfi-A in hippocampal primary cell culture show that NG FI-A is necessary for serotonin-induced DNA demethylation and increased exon17 GR promoter expression.
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Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure
Zhonghui Guan,Maurizio Giustetto,Maurizio Giustetto,Stavros Lomvardas,Joung Hun Kim,Maria Concetta Miniaci,James H. Schwartz,Dimitris Thanos,Eric R. Kandel,Eric R. Kandel +9 more
TL;DR: Aplysia finds that when a sensory neuron simultaneously receives inputs from the facilitatory transmitter 5-HT at one set of synapses and the inhibitory transmitter FMRFamide at another, long-term facilitation is blocked and synapse-specific long- term depression dominates.