Epigenetic codes in cognition and behaviour.
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Cites background from "Epigenetic codes in cognition and b..."
...[From Gräff and Mansuy (82), with permission from Elsevier....
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...[From Gräff and Mansuy (82), with permission from Elsevier.]...
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References
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"Epigenetic codes in cognition and b..." refers background in this paper
...Further, a deficiency in MBD1, a methylated NA-associated transcriptional repressor, reduces hippocampal TP, presumably through an effect on gene expression [43]....
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...howed that mice lacking MBD1, a transcriptional co-repressor hat binds methylated DNA, have impaired spatial memory on water maze [43]....
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...irs spatial memory Hippocampus Mice [43] 1, a memory eased while memory promoting ntext learning Hippocampus Rats [48]...
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...ces LTP Hippocampus Mice [43] ctivity blocks LTP Hippocampus Mice [42]...
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...In ontrast, BDNF expression is significantly upregulated and H4 yperacetylated at BDNF promoter P2 by pilocarpine treatment. lectroconvulsive seizures (ECS) also modulate H4 acetylation n the promoter region of c-Fos, BDNF and CREB genes, and corelate with altered mRNA expression in that H4 hyperacetylation s associated with increased gene expression and vice versa [45]. owever, there is no clear correlation for H3 acetylation on K9 or 14, or for the combined phosphorylation/acetylation of Ser10 nd K14, suggesting a general role for H4 acetylation but a more Brain area Organism References ces LTP Hippocampus Mice [43] ctivity blocks LTP Hippocampus Mice [42] irs spatial memory Hippocampus Mice [43] 1, a memory eased while memory promoting ntext learning Hippocampus Rats [48] 4K8 acetylation on AT CBP Sensory-motor neurons Aplysia [29] ion is accompanied tion Hippocampus Rats [36] X repressor group of y is accompanied by Hippocampus Mice [38] in H2B e-phase LTP Hippocampus Mice [39] Bdnf, H4 R2 observed in acute cetylation only in Hippocampus Rats [44,45] APK is regulating in novel taste Insular cortex Mice [49] loinsufficiency Hippocampus and forebrain Mice [39,50] spatial memory Hippocampus Mice [51] creased by spatial Hippocampus Rats [36] Bdnf promoters is d fear Prefrontal cortex Mice [55] is regulated by the nd increased upon ning Hippocampus Rats [53] g protein; C/EBP, CCAAT/enhancer binding protein; DNMT1, DNA methyl HAT, histone acetyl transferase; LTF, long-term facilitation; LTP, long-term protein 1; NMDA, N-methyl d-aspartate; PP1, protein phosphatase 1....
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385 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...Both in vitro and in vivo, NA hypermethylation decreases reln expression, an effect that s reversed by 5-aza in vitro [90,91]....
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...Furthermore, TSA and alproic acid in vitro (but also in vivo for valproic acid) can ctivate reln expression, an effect that in vivo correlates with an verall increase in H3 acetylation [91]....
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...[91] Tremolizzo L, Carboni G, Ruzicka WB, Mitchell CP, Sugaya I, Tueting...
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382 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...[123] Cropley JE, Suter CM, Beckman KB, Martin DI....
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...Strikingly, such induced epigenetic modfication can be passed to subsequent generations through both aternal [119] and paternal [123] germline, suggesting a DNA ethylation-dependent transgenerational epigenetic inheritance nduced by nutrition....
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379 citations
"Epigenetic codes in cognition and b..." refers background in this paper
...[8] Nathan D, Ingvarsdottir K, Sterner DE, Bylebyl GR, Dokmanovic M, Dorsey LA, et al....
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...In yeast, it occurs n all four core histones and negatively regulates transcription, ossibly by interfering with histone acetylation and ubiquiination [8,19]....
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