Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity
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Cites background from "Epigenetic Gene Promoter Methylatio..."
...In addition to H19/IGF2, retinoid X receptor alpha (RXR-α) appears to be modified in association with maternal folate intake during the prenatal period (60), which is of key interest because RXR-α is known to play a role in later-life obesity and metabolic disorders....
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"Epigenetic Gene Promoter Methylatio..." refers background in this paper
...Genome-wide association studies suggest that fixed genetic variation makes a relatively small contribution to risk of obesity, heart disease, and diabetes (1,2); our findings raise the possibility that the developmental environment component may be equally or more important....
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...Diabetes 60:1528–1534, 2011 Fixed genomic variations explain only a fraction of the risk of human obesity and metabolic disease (1,2)....
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3,290 citations
"Epigenetic Gene Promoter Methylatio..." refers background in this paper
...Many epidemiological studies have shown associations between fetal development, through the proxy measure of birth size, and later adiposity and metabolic function (3,4), but the developmental contribution to such phenotypic characteristics has remained uncertain and controversial....
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...Although epigenetic processes operating in early development have been implicated in the origins of obesity (3,11), there is as yet no direct evidence for this proposition in humans....
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...However, there is increasing epidemiological evidence linking perinatal factors to later adiposity and metabolic disease risk (3,4)....
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"Epigenetic Gene Promoter Methylatio..." refers background in this paper
...In vitro fertilization increases risk of imprinting disorders (44), and methylation effects on imprinted genes have been reported in offspring of mothers exposed to famine during various periods of pregnancy (45,46), but with no associations with phenotype reported....
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2,378 citations