Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice.
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Cites background from "Epigenetic modifications of GABAerg..."
...After prenatal stress in mice, abnormalities in DNA methylation have been described in GABAergic neurons and been related to a schizophrenia-like behavioral phenotype (Matrisciano et al., 2013)....
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Cites background from "Epigenetic modifications of GABAerg..."
...Mice exposed to stress in utero exhibit altered biochemical features and behaviors reminiscent of morbidities encountered in SZ and BP+ patients after reaching adulthood (Matrisciano et al, 2011, 2012a)....
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...…brain function have yet to be elucidated, recent studies support the view that early life stresses alter processes associated with chromatin remodeling such that transcriptional regulation is abnormal in distinct anatomical structures of the brain (Matrisciano et al, 2012a; McGowan et al, 2011)....
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