Epigenetics and the placenta
Citations
566 citations
Cites background from "Epigenetics and the placenta"
...Disturbance, which can be caused by various environmental factors including in vitro culture, can lead to abnormal placental development and function with possible consequences for maternal morbidity, fetal development and disease susceptibility in later life (Nelissen et al., 2011)....
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394 citations
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308 citations
Cites background from "Epigenetics and the placenta"
...The epigenetic regulation of the placenta evolves during preimplantation development (Nelissen et al., 2011)....
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...Nelissen et al. (2011) discussed whether this effect was through epigenetic disturbances of imprinted genes in fetal or placental tissues....
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285 citations
Cites background from "Epigenetics and the placenta"
...Unidentified placental functions are postulated to rely on imprinting, because imprinted genes are abundantly expressed in the placenta, compared with other organs, and imprinting arose during mammalian evolution (Nelissen et al. 2011)....
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...Epigenetic regulation of placental function changes during gestation (reviewed in Nelissen et al. 2011), accompanied by a dynamic process of loss of imprinting postulated to have an important role in placental maturation and function (Pozharny et al. 2010)....
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References
6,691 citations
"Epigenetics and the placenta" refers background in this paper
...The importance of DNA methylation for gene expression, and especially for transcriptional silencing, is apparent in the exceptions to the rule that CpG islands associated with gene promoter regions are unmethylated (Bird, 2002)....
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5,708 citations
"Epigenetics and the placenta" refers background in this paper
...Accumulating evidence describes the central role of DNA methylation in repression of retroviruses and retrotransposons, as well as genomic imprinting (Yoder et al., 1997; Okano et al., 1999; Bourc’his et al., 2001; Hata et al., 2002; Bourc’his and Bestor, 2004; Kaneda et al., 2004)....
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3,998 citations
3,994 citations
"Epigenetics and the placenta" refers background in this paper
...…knockout mice studies of DNA methyltransferases Dnmt1 and Dnmt3L have shown that the placentas of these homozygous mice exhibit multiple morphological defects, like chorioallantoic fusion defects and lack of labyrinth formation (Li et al., 1992; Bourc’his et al., 2001; Arima et al., 2006)....
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...Epigenetic regulation controls transcription at three levels, which are also displayed in the placenta: DNA (DNA methylation), protein (histone modifications) and RNA (non-coding RNAs)....
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3,412 citations
"Epigenetics and the placenta" refers background in this paper
...In the past years, it has been discovered that the majority of the mammalian genome is transcribed and that these transcripts mainly consist of non-coding (nc) RNAs (Okazaki et al., 2002; Carninci et al., 2005; Katayama et al., 2005; Engstrom et al., 2006)....
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