Journal ArticleDOI
Epinigericin toxicity towards Tetrahymena pyriformis GL; changes in cell volume and intracellular pH
Reads0
Chats0
TLDR
A study of the toxicity of epinigericin towards the ciliate Tetrahymena pyriformis showed that this molecule stopped cell division, increased cell volume and led to a more basic intracellular pH.Abstract:
A study of the toxicity of epinigericin, an antibiotic ionophor, towards the ciliate Tetrahymena pyriformis showed that this molecule stopped cell division, increased cell volume and led to a more basic intracellular pH. The action of epinigericin was probably linked to its function as an ionophor. The ionic selectivity of this molecule is still not known. The raising of the intracellular pH of ciliates by this antibiotic may be linked to its toxic action and its ion-transport mechanism in Tetrahymena. *** DIRECT SUPPORT *** AG903066 00009read more
Citations
More filters
Journal ArticleDOI
Identification of a multidrug resistance‐like system in Tetrahymena pyriformis: evidence for a new detoxication mechanism in freshwater ciliates
TL;DR: The data indicate that the accumulation of these compounds by ciliate cells is significantly enhanced in the presence of cyclosporin, which suggests that Tetrahymena is provided with a P‐ gp‐like system that is functionally active in a way similar to that of the mammalian P‐gp.
Journal ArticleDOI
Physiological, morphological and metabolic changes in Tetrahymena pyriformis for the in vivo cytotoxicity assessment of metallic pollution: Impact on d-β-hydroxybutyrate dehydrogenase
Driss Mountassif,Mostafa Kabine,Rachid Manar,Noureddine Bourhim,Zaina Zaroual,Norbert Latruffe,M'Hammed Saïd El Kebbaj +6 more
TL;DR: The results obtained reveal that the individual cytotoxicity of cadmium chloride, iron sulphate and chromium nitrate has perturbed the physiology and morphology of T. pyriformis.
Journal ArticleDOI
Nigericin and grisorixin methyl ester from the Algerian soil-living Streptomyces youssoufiensis SF10 strain: a computational study on their epimeric structures and evaluation of glioblastoma stem cells growth inhibition
Nassima Leulmi,Denise Sighel,Andrea Defant,Karima Khenaka,Abderrahmane Boulahrouf,Ines Mancini +5 more
TL;DR: This analysis was able to provide the relative stability of the most favored epimers, setting the basis for general structural considerations applicable to several other polyethers.
Journal ArticleDOI
Synthesis of CdS1-XSeX quantum dots in a protozoa Tetrahymena pyriformis
Yin-Hua Cui,Yin-Hua Cui,Ling-Li Li,Li-Jiao Tian,Nan-Qing Zhou,Dong-Feng Liu,Paul K.S. Lam,Han-Qing Yu +7 more
TL;DR: The biosynthesis of QDs by Tetrahymena pyriformis, a typical protozoa in aquatic environments, was achieved for the first time and had a great potential to be applied for Cd2+ detection.
Journal ArticleDOI
Enhanced Production and Quantitative Evaluation of Nigericin from the Algerian Soil-Living Streptomyces youssoufiensis SF10 Strain
Nassima Leulmi,Denise Sighel,Andrea Defant,Karima Khenaka,Abderrahmane Boulahrouf,Ines Mancini +5 more
TL;DR: The HPLC-ELSD method, optimized here for the quantitative detection of nigericin, can find wider applications in the analysis of several other metabolites characterized by a similar polycyclic polyether structure or, more generally, by the lack of significant chromophores in their molecular structure.
References
More filters
Journal ArticleDOI
Ion regulation in tetrahymena
Philip B. Dunham,F. M. Child +1 more
TL;DR: The main findings were: K and a small amount of Na are maintained in very dilute medium and K is specifically accumulated and retained by a system of internal binding sites with a saturation level.
Journal ArticleDOI
Étude comparée de trois antibiotiques ionophores: X.537 A (lasalocide), A.23187 (calcimycine) et X.14547 A. Complexation des cations IA et IIA, transport de Ca++
TL;DR: Using a potentiometric method, both the stoechiometry and the stability of complexes formed in methanol between the three natural ionophores and cations IA and IIA have been obtained.
Journal ArticleDOI
Epinigericin, a new polyether carboxylic antibiotic. Structural determination by 2D NMR methods
Journal ArticleDOI
Ion regulation and membrane potential in tetrahymena and paramecium
J.G Connolly,G.A. Kerkut +1 more
TL;DR: The authors suggest that an electrogenic, ouabain sensitive Na+-K+ Mg2+-ATPase is associated with the contractile vacuole and that it makes an immediate and significant contribution to the resting potential.
Journal ArticleDOI
Grisorixin, an ionophorous antibiotic of the nigericin group. Part IV. Complexation of monovalent cations
TL;DR: In this paper, data on interactions between monovalent alkali metal, thallium, and silver cations and a new antibiotic grisorixin in methanol are reported.
Related Papers (5)
Synchronous divisions in Tetrahymena pyriformis as studied in an inorganic medium; the effect of 2,4-dinitrophenol.
Kirsten Hamburger,Erik Zeuthen +1 more