Epithelial–mesenchymal plasticity in carcinoma metastasis
Citations
1,531 citations
Cites background from "Epithelial–mesenchymal plasticity i..."
...Since EMT is widely regarded to have an important role in the progression of carcinomas to metastasis (Scheel and Weinberg, 2012; Tsai and Yang, 2013) it will be interesting to examine the influence of QKI-mediated circRNAs in cancers....
[...]
1,194 citations
Cites background from "Epithelial–mesenchymal plasticity i..."
...Moreover, many of the mechanisms that are involved in inducing EMT are also capable of maintaining the dormant state of circulating cancer cells (140)....
[...]
...This in turn promotes the synthesis of type I collagen and fibronectin, which contribute further to EMT (140)....
[...]
...In addition to participating in the signaling pathways discussed above, many of these ligands also increase cell proliferation and contribute to the formation of partial EMT (140)....
[...]
931 citations
803 citations
Cites background from "Epithelial–mesenchymal plasticity i..."
...Moreover, the strength of metastasis is associated to the epithelial-to-mesenchymal transition (EMT) [214]....
[...]
...There is robust evidence that polyphenols compounds can modulate EMT and its related signaling pathways [215]....
[...]
...Abbreviations ROS Reactive oxygen species COX Cyclooxygenase NOX NADPH oxidase SOD Superoxide dismutase GSH Glutathione Px Peroxidase PLA2 Phospholipase A2 PGs Prostaglandins LTs Leukotrienes MAPK Mitogen-activated protein Kinase IKK Inhibitor of kappa kinase NFκB Nuclear factor kappa-light-chain-enhancer of activated B cells Th1 T helper 1 NK Natural killer DCs Dendritic cells ECGC Epigallocatechin gallate Treg Regulatory T cells AhR Aryl hydrocarbon receptor iNOS Inducible nitric oxide synthase LPS Lipopolysaccharide MCP-1 Monocyte chemoattractant protein-1 VEGF Vascular endothelial growth Factor IL Interleukin JNK c-Jun amino-terminal kinases CREB cAMP response element-binding protein AA Arachidonic acid AMPK AMP-activated protein kinase ERK Extra-cellular signal regulated kinases ATP Adenosine triphosphate CVD Cardiovascular disease PI3K Phosphatidylinositide 3-kinases Akt Protein kinase B LDL Low density lipoprotein HDL High density lipoprotein RNS Reactive nitrogen species PPARγ Peroxisome proliferator-activated receptor gamma CYPs Cytochrome P450 enzymes MMP-9 Matrix metallopeptidase-9 NPC Nasopharyngeal carcinoma CSCs Cancer stem cells EMT Epithelial-to-mesenchymal transition FDA Food and drug administration ICAM Intercellular adhesion molecule VCAM Vascular cell adhesion molecule HIV Human immunodeficiency diarrhea HMG-CoA 3-Hydroxy-3-methyl-glutaryl-coenzyme A VEGF Vascular endothelial growth factor TLR Toll-like receptor NO Nitric oxide eNOS Endothelial nitric oxide synthase PDE Phosphodiesterase ACE Angiotensin converting enzyme...
[...]
737 citations
References
51,099 citations
"Epithelial–mesenchymal plasticity i..." refers background in this paper
...One of the major sources of TGF-b in tumors is the stromal fibroblast cells in the tumor microenvironment (Hanahan and Weinberg 2011)....
[...]
10,791 citations
"Epithelial–mesenchymal plasticity i..." refers background in this paper
...Further analysis of these invasive basal/triple-negative subgroups found tumor cells that are double-positive for keratin and vimentin at the invasive front (Sorlie et al. 2001; Livasy et al. 2006; Rakha et al. 2006; Bonnomet et al. 2012)....
[...]
10,058 citations
"Epithelial–mesenchymal plasticity i..." refers background in this paper
...In breast cancer patients, disseminated breast cancer cells from pleural effusions, which likely have undergone EMT, are enriched for a CD44high, CD24low CSC-like population (Al-Hajj et al. 2003)....
[...]
...In breast cancer patients, disseminated breast cancer cells from pleural effusions, which likely have undergone EMT, are enriched for a CD44, CD24 CSC-like population (Al-Hajj et al. 2003)....
[...]
8,642 citations
"Epithelial–mesenchymal plasticity i..." refers background in this paper
...Twist1 (Thiery et al. 2009; Eckert et al. 2011)....
[...]
...For example, TGF-b and BMPs have been shown to induce the EMT core transcription factors Snail1/2, Zeb1/2, and GENES & DEVELOPMENT 2193 Twist1 (Thiery et al. 2009; Eckert et al. 2011)....
[...]
...Given that a number of recent reviews have focused on the molecular pathways regulating EMT/MET (Thiery et al. 2009; De Craene and Berx 2013; Zheng and Kang 2013), this section aims to provide an overview of the cellular and molecular definition for EMT/MET and establish a foundation for detailed discussions of these pathways in the context of tumor metastasis....
[...]
...These epithelial cells can activate a transitory EMT program and then undergo a reverse process called mesenchymal–epithelial transition (MET) to continue their differentiation paths (Thiery et al. 2009; LimandThiery 2012)....
[...]
...These epithelial cells can activate a transitory EMT program and then undergo a reverse process called mesenchymal–epithelial transition (MET) to continue their differentiation paths (Thiery et al. 2009; Lim and Thiery 2012)....
[...]
8,587 citations
"Epithelial–mesenchymal plasticity i..." refers background in this paper
...…stromal environment, an even smaller subset of tumor cells establish micrometastases with the potential to proliferate into fully malignant, secondary tumors that are clinically detectable and eventually life-threatening (step V: colonization) (Thiery 2002; Fidler 2003; Kalluri and Weinberg 2009)....
[...]