Journal ArticleDOI
Erythrocyte membrane sodium — potassium adenosine triphosphatase activity in affective disorders
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TLDR
Monitoring of Na+,K+-ATPase activity during lithium therapy is useful to predict a therapeutic response, and the lithium responders showed a significant increase in Na+K-ATpase activity compared to lithium nonresponders.Abstract:
Erythrocyte membrane Na+,K+-ATPase activity was studied in drug naive patients with bipolar (BP) mania (n=62) and unipolar (UP) depression (n=60) and normal controls (n=66). Compared to controls there was a significantly decreased Na+,K+-ATPase activity in UP depressives but no change in BP manics. However, lithium treatment caused a significant increase in Na+,K+-ATPase activity although there was no correlation between plasma lithium levels and enzyme activity. Plasma cortisol correlated inversely with Na+,K+-ATPase in UP depressives. Interestingly, the lithium responders [ 50% BRMS score). These observations indicate that monitoring of Na+,K+-ATPase activity during lithium therapy is useful to predict a therapeutic response.read more
Citations
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Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics
TL;DR: There is inherent value and need for studies of lithium responders, as full responders to lithium seem to represent a unique clinical population, and such studies will be an opportunity to uncover specific effects of lithium in those individuals who clearly benefit from the treatment.
Journal ArticleDOI
The Na,K-ATPase hypothesis for bipolar illness.
TL;DR: A reduction in Na,K-ATPase activity can lead to both mania and depression by increasing membrane excitability and decreasing neurotransmitter release, respectively.
Journal ArticleDOI
Reduction of Hippocampal Na + , K + -ATPase Activity in Rats Subjected to an Experimental Model of Depression
Giovana Duzzo Gamaro,Emilio L. Streck,Cristiane Matté,Martha Elisa Prediger,Angela T. S. Wyse,Carla Dalmaz +5 more
TL;DR: The effect of a model of depression using female rats on Na+, K+-ATPase activity in hippocampal synaptic plasma membranes was studied and treatment with fluoxetine increased this enzyme activity and reversed the effect of stress.
Journal ArticleDOI
Effects of lithium therapy on Na+-K+-ATPase activity and lipid peroxidation in bipolar disorder.
TL;DR: Lithium induced improvement in the enzyme activity was associated with significant reduction in lipid peroxidation and enhancement of the Na(+)-K(+-ATPase activity by optimum dosage of lithium may be a potential contributing factor for reducing oxidative stress in BPD patients.
Journal ArticleDOI
Effects of mood stabilizers on hippocampus and amygdala BDNF levels in an animal model of mania induced by ouabain.
Luciano K. Jornada,Morgana Moretti,Samira S. Valvassori,Camila L. Ferreira,Peterson Teodoro Padilha,Camila O. Arent,Gabriel Rodrigo Fries,Flávio Kapczinski,João Quevedo +8 more
TL;DR: The results suggest that the present model fulfills adequate face, construct and predictive validity as an animal model of mania.
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