Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
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...Third, in other regions — for example the VTA and NAc — BDNF exerts a potent pro-depressant effect: chronic stress increases the amount of BDNF within the NA...
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1,863 citations
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...Increased BDNF Signaling within the NAc Mediates Susceptibility Because chronic social defeat increases BDNF protein levels in the NAc on days 11 and 39 (Berton et al., 2006), we tested whether this response differs between Susceptible and Unsusceptible mice....
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...Subjects and Drugs Male 7-week-old c57bl/6 (Jackson), CD1 retired breeders (Charles River), 9- to 13-week-old floxed BDNF mice (Berton et al., 2006), and 10- to 14-week-old BDNF Met/Met and Val/Val mice (Chen et al....
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...To test this prediction, we examined the behavioral effects of an established method to locally delete the bdnf gene from the NAc by stereotaxically infusing adenoassociated virus (AAV) that expresses Cre-recombinase into the NAc of floxed BDNF mice (Berton et al., 2006; Graham et al., 2007)....
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...33 gauge needles were used to bilaterally infuse 0.5 ml of virus (or BDNF) into NAc or VTA at a rate of 0.1 ml/min (Berton et al., 2006)....
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...We have previously shown that c57bl/6 mice subjected to chronic social defeat (10 such defeats over 10 days) display a long-lasting reduction in social interaction (Berton et al., 2006; Tsankova et al., 2006), which is measured by comparing the time a mouse spends in an interaction zone with a social target to the time in that zone in the absence of a social target....
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1,859 citations
1,841 citations
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...in various brain regions [42,43], it is reasonable to postulate that improving BDNF function may be beneficial to the hippocampal neurons that are susceptible to stress-induced damages....
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1,691 citations
References
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