Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19.
Kimon Stamatelopoulos,Kimon Stamatelopoulos,Georgios Georgiopoulos,Georgios Georgiopoulos,Kenneth F Baker,Kenneth F Baker,Giusy Tiseo,Dimitrios Delialis,Charalampos Lazaridis,Charalampos Lazaridis,Greta Barbieri,Stefano Masi,Nikolaos I. Vlachogiannis,Kateryna Sopova,Kateryna Sopova,Alessandro Mengozzi,Lorenzo Ghiadoni,Ina Schim van der Loeff,Aidan T Hanrath,Bajram Ajdini,Charalambos Vlachopoulos,Meletios A. Dimopoulos,Christopher J A Duncan,Christopher J A Duncan,Marco Falcone,Konstantinos Stellos,Konstantinos Stellos +26 more
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In this article, the authors evaluated the prognostic role of estimated pulse wave velocity (ePWV), a marker of arterial stiffness which reflects overall arterial integrity and aging, in risk stratification of hospitalized patients with COVID-19.Abstract:
Accurate risk stratification in COVID-19 patients consists a major clinical need to guide therapeutic strategies. We sought to evaluate the prognostic role of estimated pulse wave velocity (ePWV), a marker of arterial stiffness which reflects overall arterial integrity and aging, in risk stratification of hospitalized patients with COVID-19. This retrospective, longitudinal cohort study, analyzed a total population of 1671 subjects consisting of 737 hospitalized COVID-19 patients consecutively recruited from two tertiary centers (Newcastle cohort: n = 471 and Pisa cohort: n = 266) and a non-COVID control cohort (n = 934). Arterial stiffness was calculated using validated formulae for ePWV. ePWV progressively increased across the control group, COVID-19 survivors and deceased patients (adjusted mean increase per group 1.89 m/s, P < 0.001). Using a machine learning approach, ePWV provided incremental prognostic value and improved reclassification for mortality over the core model including age, sex and comorbidities [AUC (core model + ePWV vs. core model) = 0.864 vs. 0.755]. ePWV provided similar prognostic value when pulse pressure or hs-Troponin were added to the core model or over its components including age and mean blood pressure (p < 0.05 for all). The optimal prognostic ePWV value was 13.0 m/s. ePWV conferred additive discrimination (AUC: 0.817 versus 0.779, P < 0.001) and reclassification value (NRI = 0.381, P < 0.001) over the 4C Mortality score, a validated score for predicting mortality in COVID-19 and the Charlson comorbidity index. We suggest that calculation of ePWV, a readily applicable estimation of arterial stiffness, may serve as an additional clinical tool to refine risk stratification of hospitalized patients with COVID-19 beyond established risk factors and scores.read more
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Vascular Dysfunction and Its Cardiovascular Consequences During and After COVID-19 Infection: A Narrative Review
TL;DR: In this paper , the authors present a narrative review to understand how COVID-19 infection deranges vascular homeostasis, leading to endothelial dysfunction and arterial stiffness in the acute phase and following infection.
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Clinical implications of vascular dysfunction in acute and convalescent COVID‐19: A systematic review
Georgios Mavraganis,M. Dimopoulou,D Delialis,D Bampatsias,Raphael Patras,A. Sianis,E. Maneta,Kimon Stamatelopoulos,Georgios Georgiopoulos +8 more
TL;DR: Vascular impairment in COVID‐19 might be associated with clinical manifestations and could refine risk stratification in patients with high-risk coronavirus disease 2019, and this context might be related to clinical manifestations in these patients.
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Acute and Long-Term Consequences of COVID-19 on Arterial Stiffness—A Narrative Review
Ioana Mădălina Zota,Cristian Stanescu,Radu Sascau,Mihai Roca,Larisa Anghel,Alexandra Mastaleru,Maria Magdalena Leon-Constantin,Cristina Mihaela Ghiciuc,Sebastian Cozma,Lucia Corina Dima-Cozma,Irina Esanu,Florin Mitu +11 more
TL;DR: Vascular physiology remains impaired at least 12 months after infection with SARS-CoV-2, even in otherwise healthy adults, raising concerns regarding the extent of arterial remodeling in patients with preexisting vascular disease and the potential development of a persistent, chronic COVID-19 vasculopathy.
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Associations between estimated and measured carotid-femoral pulse wave velocity in older Black and White adults: the atherosclerosis risk in communities (ARIC) study
Kevin S. Heffernan,Lee Stoner,Michelle L. Meyer,Adam W Keifer,Lauren C. Bates,Patricia Pagan Lassalle,Erik D. Hanson,Masahiro Horiuchi,Erin D. Michos,Anna Kucharska-Newton,Kunihiro Matsushita,Timothy M. Hughes,Hirofumi Tanaka +12 more
TL;DR: Estimated pulse wave velocity is weakly associated with measured carotid-femoral pulseWave velocity in older Black and White adults in ARIC, suggesting a weak association between ePWV and cfPWVs in older White and Black adults from ARIC.
Journal ArticleDOI
Utility of Estimated Pulse Wave Velocity for Tracking the Arterial Response to Prolonged Sitting
TL;DR: In this article , the effects of time on arterial stiffness, measured by pulse wave velocity (PWV), and carotid-radial (CR) responses to an acute bout of prolonged sitting with mathematically estimated PWV were investigated.
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