Journal ArticleDOI
Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013.
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TLDR
This first global assessment of country-level population prevalence of chronic HBV infection found a wide variation between countries and highlights the need for continued prevention and control strategies and the collection of reliable epidemiologic data using standardised methodology.About:
This article is published in The Lancet.The article was published on 2015-10-17. It has received 2130 citations till now. The article focuses on the topics: HBsAg & Hepatitis B virus.read more
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New therapeutic agents for chronic hepatitis B
TL;DR: This Review provides a summary of available regimens with their strengths and limitations, and highlights future therapeutic strategies to target the virus and host immune response.
Journal ArticleDOI
The microRNA‐99 family modulates hepatitis B virus replication by promoting IGF‐1R/PI3K/Akt/mTOR/ULK1 signaling‐induced autophagy
Yong Lin,Wanyu Deng,Jinke Pang,Thekla Kemper,Jing Hu,Jing Hu,Jian Yin,Jiming Zhang,Mengji Lu +8 more
TL;DR: Experimental data demonstrated that the miR‐99 family promoted autophagy through mTOR/ULK1 signaling and thereby enhanced hepatitis B virus replication and promotes HBV replication posttranscriptionally through IGF‐1R/PI3K/Akt/mTOR/ulk1 signaling‐inducedAutophagy.
Journal ArticleDOI
Treatment of chronic hepatitis B naïve patients with a therapeutic vaccine containing HBs and HBc antigens (a randomized, open and treatment controlled phase III clinical trial).
Mamun Al Mahtab,Sheikh Mohammad Fazle Akbar,Julio C Aguilar,Gerardo Guillén,Euduaro Penton,Angela Tuero,Osamu Yoshida,Yoichi Hiasa,Morikazu Onji +8 more
TL;DR: Nasvac induced a superior reduction of the viral load under the limit of detection compared to Peg-IFN treatment, and is a safe and efficacious finite alternative of antiviral treatment for CHB patients.
Journal ArticleDOI
Safety and efficacy of vesatolimod (GS-9620) in patients with chronic hepatitis B who are not currently on antiviral treatment.
Kosh Agarwal,Sang Hoon Ahn,M. Elkhashab,Audrey H. Lau,Anuj Gaggar,A. Bulusu,X. Tian,A. L. Cathcart,J. Woo,G.M. Subramanian,Pietro Andreone,Hyung Joon Kim,Wan-Lung Chuang,Mindie H. Nguyen +13 more
TL;DR: Overall, vesatolimod is safe and well tolerated in CHB patients and consistent dose‐dependent pharmacodynamic induction of ISGs was demonstrated, and it did not result in clinically significant HBsAg decline.
Journal ArticleDOI
Comparison of clinical practice guidelines for the management of chronic hepatitis b: When to start, when to change, and when to stop
Hyung Joon Yim,Ji Hoon Kim,Jun Yong Park,Eileen L. Yoon,Hana Park,Jung Hyun Kwon,Dong Hyun Sinn,Sae Hwan Lee,Jeong Hoon Lee,Hyun Woong Lee +9 more
TL;DR: This review compares the similarities and differences among the various practice guidelines for the management of chronic hepatitis B to identify unmet needs and improve future recommendations.
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R: A language and environment for statistical computing.
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
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Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
TL;DR: Moher et al. as mentioned in this paper introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses, which is used in this paper.
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Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
TL;DR: The QUOROM Statement (QUality Of Reporting Of Meta-analyses) as mentioned in this paper was developed to address the suboptimal reporting of systematic reviews and meta-analysis of randomized controlled trials.
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Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
TL;DR: A structured summary is provided including, as applicable, background, objectives, data sources, study eligibility criteria, participants, interventions, study appraisal and synthesis methods, results, limitations, conclusions and implications of key findings.
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Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013
Mohsen Naghavi,Haidong Wang,Rafael Lozano,Adrian Davis,Xiaofeng Liang,Maigeng Zhou,Stein Emil Vollset,Stein Emil Vollset,Stein Emil Vollset,Ayse Abbasoglu Ozgoren,Safa Abdalla,Foad Abd-Allah,M A Aziz,Semaw Ferede Abera,Victor Aboyans,Biju Abraham,Jerry Puthenpurakal Abraham,Katrina Abuabara,Ibrahim Abubakar,Laith J. Abu-Raddad,Niveen M E Abu-Rmeileh,Tom Achoki,Ademola Lukman Adelekan,Zanfina Ademi,Koranteng Adofo,Arsène Kouablan Adou,Jose C. Adsuar,Johan Ärnlöv,Emilie Agardh,Dickens Akena,Mazin J. Al Khabouri,Deena Alasfoor,Mohammed I. Albittar,Miguel Angel Alegretti,Alicia Aleman,Zewdie Aderaw Alemu,Rafael Alfonso-Cristancho,Samia Alhabib,Mohammed K. Ali,Raghib Ali,François Alla,Faris Al Lami,Peter Allebeck,Mohammad A. AlMazroa,Rustam Al-Shahi Salman,Ubai Alsharif,Elena Alvarez,Nelson Alviz-Guzman,Adansi A. Amankwaa,Azmeraw T. Amare,Omid Ameli,Hassan Amini,Walid Ammar,H. Ross Anderson,Benjamin O. Anderson,Carl Abelardo T. Antonio,Palwasha Anwari,Henry Apfel,Solveig A. Cunningham,Valentina Arsić Arsenijević,Al Artaman,Majed Asad,Rana J. Asghar,Reza Assadi,Lydia S. Atkins,Charles Atkinson,Alaa Badawi,Maria Cecilia Bahit,Talal Bakfalouni,Kalpana Balakrishnan,Shivanthi Balalla,Amitava Banerjee,Ryan M Barber,Suzanne Barker-Collo,Simón Barquera,Lars Barregard,Lope H Barrero,Tonatiuh Barrientos-Gutiérrez,Arindam Basu,Sanjay Basu,Mohammed Basulaiman,Justin Beardsley,Neeraj Bedi,Ettore Beghi,Tolesa Bekele,Michelle L. Bell,Corina Benjet,Derrick A Bennett,Isabela M. Benseñor,Habib Benzian,Amelia Bertozzi-Villa,Tariku Jibat Beyene,Neeraj Bhala,Ashish Bhalla,Zulfiqar A Bhutta,Boris Bikbov,Aref A. Bin Abdulhak,Stan Biryukov,Jed D. Blore,Fiona M. Blyth,Megan Bohensky,Guilherme Borges,Dipan Bose,Soufiane Boufous,Rupert R A Bourne,Lindsay N. Boyers,Michael Brainin,Michael Brauer,Carol Brayne,Alexandra Brazinova,Nicholas J K Breitborde,Hermann Brenner,Adam D M Briggs,J Brown,Traolach S. Brugha,Geoffrey Buckle,Linh N Bui,Gene Bukhman,Michael Burch,Ismael Ricardo Campos Nonato,Hélène Carabin,Rosario Cárdenas,Jonathan R. Carapetis,David O. Carpenter,Valeria Caso,Carlos A Castañeda-Orjuela,Ruben Castro,Ferrán Catalá-López,Fiorella Cavalleri,Jung-Chen Chang,Jung-Chen Chang,Fiona C. Charlson,Xuan Che,Honglei Chen,Yingyao Chen,Jian Sheng Chen,Zhengming Chen,Peggy Pei-Chia Chiang,Odgerel Chimed-Ochir,Rajiv Chowdhury,Hanne Christensen,Costas A. Christophi,Ting Wu Chuang,Sumeet S. Chugh,Massimo Cirillo,Matthew M Coates,Luc E. Coffeng,Megan Coggeshall,Aaron Cohen,Valentina Colistro,Samantha M. Colquhoun,Mercedes Colomar,Leslie T. Cooper,Cyrus Cooper,Luis M. Coppola,Monica Cortinovis,Karen J. Courville,Benjamin C Cowie,Michael H. Criqui,John A. Crump,Lucía Cuevas-Nasu,Iuri da Costa Leite,Kaustubh Dabhadkar,Lalit Dandona,Lalit Dandona,Rakhi Dandona,Emily Dansereau,Paul I. Dargan,Anand Dayama,Vanessa De la Cruz-Góngora,Shelley F. De La Vega,Diego De Leo,Louisa Degenhardt,Borja del Pozo-Cruz,Robert P. Dellavalle,Kebede Deribe,Don C. Des Jarlais,Muluken Dessalegn,Gabrielle de Veber,Samath D Dharmaratne,Mukesh Dherani,José Luis Díaz-Ortega,Cesar Diaz-Torne,Daniel Dicker,Eric L. Ding,Klara Dokova,E. Ray Dorsey,Tim Driscoll,Leilei Duan,Herbert C. Duber,Adnan M. Durrani,Beth E. Ebel,Karen Edmond,Richard G. Ellenbogen,Yousef M. Elshrek,Sergey Petrovich Ermakov,Holly E. Erskine,Babak Eshrati,Alireza Esteghamati,Kara Estep,Thomas Fürst,Saman Fahimi,Anna S. Fahrion,Emerito Jose A. Faraon,Farshad Farzadfar,Derek F J Fay,Andrea B. Feigl,Valery L. Feigin,Manuela Mendonca Felicio,Seyed-Mohammad Fereshtehnejad,Jefferson G Fernandes,Alize J. Ferrari,Thomas D. Fleming,Nataliya Foigt,Kyle J Foreman,Mohammad H. Forouzanfar,F. Gerry R. Fowkes,Urbano Fra Paleo,Richard C. Franklin,Neal D. Futran,Lynne Gaffikin,Ketevan Gambashidze,Fortuné Gbètoho Gankpé,Francisco A García-Guerra,Ana C. Garcia,Johanna M. Geleijnse,Bradford D. Gessner,Katherine B Gibney,Richard F. Gillum,Stuart Gilmour,Ibrahim Abdelmageem Mohamed Ginawi,Maurice Giroud,Elizabeth Glaser,Shifalika Goenka,Héctor Gómez Dantés,Philimon Gona,Diego Gonzalez-Medina,Caterina Guinovart,Rashmi Gupta,Rajeev Gupta,Richard A. Gosselin,Carolyn C. Gotay,Atsushi Goto,Hebe N. Gouda,Nicholas Graetz,K. Fern Greenwell,Harish Chander Gugnani,David Gunnell,Reyna A Gutiérrez,Juanita A. Haagsma,Nima Hafezi-Nejad,Holly Hagan,Maria Hagströmer,Yara A. Halasa,Randah R. Hamadeh,Hannah Hamavid,Mouhanad Hammami,Jamie Hancock,Graeme J. Hankey,Gillian M. Hansen,Hilda L Harb,Heather Harewood,Josep Maria Haro,Rasmus Havmoeller,Roderick J. Hay,Simon I. Hay,Mohammad Taghi Hedayati,Ileana B. Heredia Pi,Kyle R. Heuton,Pouria Heydarpour,Hideki Higashi,Martha Híjar,Hans W. Hoek,Howard J. Hoffman,John Hornberger,H. Dean Hosgood,Mazeda Hossain,Peter J. Hotez,Damian G Hoy,Damian G Hoy,Mohamed Hsairi,Guoqing Hu,John J Huang,Mark D. Huffman,Andrew J. Hughes,Abdullatif Husseini,Chantal Huynh,Marissa Iannarone,Kim Moesgaard Iburg,Bulat Idrisov,Nayu Ikeda,Kaire Innos,Manami Inoue,Farhad Islami,Samaya Ismayilova,Kathryn H. Jacobsen,Simerjot K. Jassal,Simerjot K. Jassal,Sudha Jayaraman,Paul N. Jensen,Vivekanand Jha,Guohong Jiang,Ying Jiang,Jost B. Jonas,Jonathan C. Joseph,Knud Juel,Edmond K. Kabagambe,Haidong Kan,André Karch,Chante Karimkhani,Ganesan Karthikeyan,Nicholas J Kassebaum,Anil Kaul,Norito Kawakami,Konstantin Kazanjan,Dhruv S. Kazi,Andrew H. Kemp,Andre Pascal Kengne,Andre Keren,Maia Kereselidze,Yousef Khader,Shams Eldin Ali Hassan Khalifa,Ejaz Ahmad Khan,Gulfaraz Khan,Young-Ho Khang,Christian Kieling,Yohannes Kinfu,Jonas Minet Kinge,Daniel Kim,Sungroul Kim,Miia Kivipelto,Luke D. Knibbs,Ann Kristin Knudsen,Yoshihiro Kokubo,Sowarta Kosen,Meera Kotagal,Michael Kravchenko,Sanjay Krishnaswami,Hans Krueger,Barthelemy Kuate Defo,Ernst J. Kuipers,Burcu Kucuk Bicer,Chanda Kulkarni,Veena S. Kulkarni,Kaushalendra Kumar,Ravi Kumar,Gene F. Kwan,Hmwe H Kyu,Taavi Lai,Arjun Lakshmana Balaji,Ratilal Lalloo,Tea Lallukka,Tea Lallukka,Hilton Lam,Qing Lan,Van C. Lansingh,Heidi J. Larson,Anders Larsson,Pablo M. Lavados,Alicia Elena Beatriz Lawrynowicz,Janet L Leasher,Jongmin Lee,James Leigh,Mall Leinsalu,Ricky Leung,Carly E Levitz,Bin Li,Yichong Li,Yongmei Li,Chelsea A. Liddell,Stephen S Lim,Graça Maria Ferreira De Lima,Maggie Lind,Steven E. Lipshultz,Shiwei Liu,Yang Liu,Belinda K Lloyd,Belinda K Lloyd,Katherine T. Lofgren,Giancarlo Logroscino,Stephanie J. London,Joannie Lortet-Tieulent,Paulo A. Lotufo,Robyn M. Lucas,Raimundas Lunevicius,Ronan A Lyons,Stefan Ma,Vasco Manuel Pedro Machado,Michael F. MacIntyre,Mark T Mackay,Jennifer H MacLachlan,Carlos Magis-Rodriguez,Abbas Ali Mahdi,Marek Majdan,Reza Malekzadeh,Srikanth Mangalam,Christopher C. Mapoma,Marape Marape,Wagner Marcenes,Christopher Margono,Guy B. Marks,Melvin Barrientos Marzan,Joseph R. Masci,Mohammad T Mashal,Felix Masiye,Amanda J. Mason-Jones,Richard Matzopolous,Bongani M. Mayosi,Tasara T. Mazorodze,John J. McGrath,Abigail C. McKay,Martin McKee,Abigail McLain,Peter A. Meaney,Man Mohan Mehndiratta,Fabiola Mejía-Rodríguez,Yohannes Adama Melaku,Michele Meltzer,Ziad A. Memish,Walter Mendoza,George A. Mensah,Atte Meretoja,Francis Apolinary Mhimbira,Ted R. Miller,Ted R. Miller,Edward J Mills,Awoke Misganaw,Santosh Mishra,Charles Mock,Terrie E. Moffitt,Norlinah Mohamed Ibrahim,Karzan Abdulmuhsin Mohammad,Ali H. Mokdad,Glen Mola,Lorenzo Monasta,Jonathan de la Cruz Monis,Julio Cesar Montañez Hernandez,Marcella Montico,Thomas J. Montine,Meghan D. Mooney,Ami R. Moore,Maziar Moradi-Lakeh,Andrew E. Moran,Rintaro Mori,Joanna Moschandreas,Wilkister N. Moturi,Madeline L. Moyer,Dariush Mozaffarian,Ulrich O Mueller,Mitsuru Mukaigawara,Erin C Mullany,Joseph Murray,Adetoun Mustapha,Paria Naghavi,Aliya Naheed,Kovin Naidoo,Luigi Naldi,Devina Nand,Vinay Nangia,K.M. Venkat Narayan,Denis Nash,Jamal Nasher,Chakib Nejjari,Robert G. Nelson,Marian L. Neuhouser,Sudan Prasad Neupane,Polly A. Newcomb,Lori M. Newman,C. R. Newton,Marie Ng,Frida Namnyak Ngalesoni,Grant Nguyen,Nhung T Nguyen,Muhammad Imran Nisar,Sandra Nolte,Ole Frithjof Norheim,Rosana E. Norman,Bo Norrving,Luke Nyakarahuka,Shaun Odell,Martin O'Donnell,Takayoshi Ohkubo,Summer Lockett Ohno,Bolajoko O. Olusanya,Saad B. Omer,John Nelson Opio,Orish Ebere Orisakwe,Katrina F Ortblad,Alberto Ortiz,Maria Lourdes K. Otayza,Amanda W Pain,Jeyaraj D Pandian,Carlo Irwin A. Panelo,Jeemon Panniyammakal,Christina Papachristou,Angel J Paternina Caicedo,Scott B. Patten,George C Patton,Vinod K. Paul,Boris I. Pavlin,Neil Pearce,Carlos A. Pellegrini,David M. Pereira,Sophie C. Peresson,Rogelio Pérez-Padilla,Fernando Perez-Ruiz,Norberto Perico,Aslam Pervaiz,Konrad Pesudovs,Carrie Beth Peterson,Max Petzold,Bryan K. Phillips,David Phillips,Michael R. Phillips,Michael R. Phillips,Dietrich Plass,Frédéric B. Piel,Dan Poenaru,Suzanne Polinder,Svetlana Popova,Richie Poulton,Farshad Pourmalek,Dorairaj Prabhakaran,Dima M. Qato,Amado D Quezada,D. Alex Quistberg,Felicia A. Rabito,Anwar Rafay,Kazem Rahimi,Vafa Rahimi-Movaghar,Sajjad Ur Rahman,Murugesan Raju,Ivo Rakovac,Saleem M Rana,Saleem M Rana,Amany H Refaat,Giuseppe Remuzzi,Antonio Luiz Pinho Ribeiro,Stefano Ricci,Patricia M. Riccio,Lee Richardson,Jan Hendrik Richardus,Bayard Roberts,D. Allen Roberts,Margaret Robinson,Anna Roca,Alina Rodriguez,David Rojas-Rueda,Luca Ronfani,Robin Room,Gregory A. Roth,Dietrich Rothenbacher,David H. Rothstein,Jane Rowley,Nobhojit Roy,George Mugambage Ruhago,Lesley Rushton,Sankar Sambandam,Kjetil Søreide,Mohammad Yahya Saeedi,Sukanta Saha,Ramesh Sahathevan,Mohammad Ali Sahraian,Berhe W. Sahle,Joshua A. Salomon,Deborah Salvo,Genesis May J. Samonte,Uchechukwu K.A. Sampson,Juan Sanabria,Logan Sandar,Itamar S. Santos,Maheswar Satpathy,Monika Sawhney,Mete Saylan,Peter Scarborough,Ben Schöttker,Jürgen C Schmidt,Ione Jayce Ceola Schneider,Austin E Schumacher,David C. Schwebel,James Scott,Sadaf G. Sepanlou,Edson Serván-Mori,Katya Anne Shackelford,Amira Shaheen,Saeid Shahraz,Marina Shakh-Nazarova,Siyi Shangguan,Jun She,Sara Sheikhbahaei,Donald S. Shepard,Kenji Shibuya,Yukito Shinohara,Kawkab Shishani,Ivy Shiue,Rupak Shivakoti,Mark G. Shrime,Inga Dora Sigfusdottir,Donald H. Silberberg,Andrea P. Silva,Edgar P. Simard,Shireen Sindi,Jasvinder A. Singh,Lavanya Singh,Edgar Sioson,Vegard Skirbekk,Karen Sliwa,Samuel So,Michael Soljak,Samir Soneji,Sergey Soshnikov,Luciano A. Sposato,Chandrashekhar T Sreeramareddy,Jeffrey D. Stanaway,Vasiliki Stathopoulou,Kyle Steenland,Claudia Stein,Caitlyn Steiner,Antony Stevens,Heidi Stöckl,Kurt Straif,Konstantinos Stroumpoulis,Lela Sturua,Bruno F. Sunguya,Soumya Swaminathan,Mamta Swaroop,Bryan L. Sykes,Karen M. Tabb,Ken Takahashi,Roberto Tchio Talongwa,Feng Tan,David Tanne,Marcel Tanner,Marcel Tanner,Mohammad Tavakkoli,Braden Te Ao,Carolina Maria Teixeira,Tara Templin,Eric Y. Tenkorang,Abdullah Sulieman Terkawi,Bernadette Thomas,Andrew L. Thorne-Lyman,Amanda G. Thrift,George D. Thurston,Taavi Tillmann,David L. Tirschwell,Imad M. Tleyjeh,Imad M. Tleyjeh,Marcello Tonelli,Fotis Topouzis,Jeffrey A. Towbin,Hideaki Toyoshima,Jefferson Traebert,Bach Xuan Tran,Thomas Truelsen,Ulises Trujillo,Matias Trillini,Zacharie Tsala Dimbuene,Miltiadis K. Tsilimbaris,E. Murat Tuzcu,Clotilde Ubeda,Uche S. Uchendu,Kingsley N. Ukwaja,Eduardo A. Undurraga,Andrew Vallely,Steven van de Vijver,Coen H. Van Gool,Yuri Y Varakin,Tommi Vasankari,Ana Maria Nogales Vasconcelos,Monica S. Vavilala,Narayanaswamy Venketasubramanian,Lakshmi Vijayakumar,Salvador Villalpando,Francesco Saverio Violante,Vasiliy Victorovich Vlassov,Gregory R. Wagner,Stephen G. Waller,JianLi Wang,Linhong Wang,Xiao Rong Wang,Yanping Wang,Tati S. Warouw,Scott Weichenthal,Elisabete Weiderpass,Robert G. Weintraub,Robert G. Weintraub,Wang Wenzhi,Andrea Werdecker,K. Ryan Wessells,Ronny Westerman,Harvey Whiteford,James D. Wilkinson,Thomas N. Williams,Solomon Meseret Woldeyohannes,Charles D.A. Wolfe,Timothy M. Wolock,Anthony D. Woolf,John Q. Wong,Jonathan L. Wright,Sarah Wulf,Brittany Wurtz,Gelin Xu,Yang Yang,Yuichiro Yano,Hiroshi Yatsuya,Paul S. F. Yip,Naohiro Yonemoto,Seok Jun Yoon,Mustafa Z. Younis,Chuanhua Yu,Kim Yun Jin,Maysaa El Sayed Zaki,Mohammed Fouad Zamakhshary,Hajo Zeeb,Yong Zhang,Yong Zhao,Yingfeng Zheng,Jun Zhu,Shankuan Zhu,David Zonies,Xiao Nong Zou,Joseph R. Zunt,Theo Vos,Alan D. Lopez,Alan D. Lopez,Christopher J L Murray,Gabriel Alcalá-Cerra,Howard Hu,Nadim E. Karam,Nsanzimana Sabin,A. M. Temesgen +731 more
TL;DR: In the Global Burden of Disease Study 2013 (GBD 2013) as discussed by the authors, the authors used the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data.
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