Estrogenic and mutagenic activities of Crotalaria pallida measured by recombinant yeast assay and Ames test
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Additional excerpts
...Stigmasterol (E) ER/Traditional medicine Boldrin et al. (2013) (R)...
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Cites background from "Estrogenic and mutagenic activities..."
...The raw leaves are very useful for abortion since it has stigmasterol which affects estrogenic activity (Boldrin et al., 2013)....
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28 citations
Additional excerpts
...Stigmasterol has anti-osteoarthritic, anti-hypercholestrolemic, cytotoxicity, antitumor, thyroid inhibiting, hypoglycemic, anti-mutagenic, antioxidant, anti-inflammatory, anticonvulsant and sedative [69], chemopreventive, anticancer, estrogenic [70] activities....
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References
7,256 citations
"Estrogenic and mutagenic activities..." refers methods in this paper
...Ames (Berkeley, CA, USA), with (+S9) and without (−S9) metabolization, using the preincubation method [23]....
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2,078 citations
"Estrogenic and mutagenic activities..." refers methods in this paper
...The extracts were monitored using TLC-silica gel 60-F254 precoated Al sheets, using chloroform: methanol: n-propanol:water (5:6:1:4, v:v) as developing solvent, visualized using UV (254 and 366 nm) and anisaldehyde sulphuric acid spray [16], until total depletion of the drug....
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605 citations
"Estrogenic and mutagenic activities..." refers background in this paper
...during menopause, without the undesirable effects of estrogen, such as the elevation of breast cancer incidence [9,10]....
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583 citations
"Estrogenic and mutagenic activities..." refers background in this paper
...The exact mechanism by which phytosteroids offer protection against cancer is not understood, but there are theories proposing their effect on the structure of cell membranes, on the fluidity of cell membranes, on enzymes bound to membranes, on signal transduction pathways, on apoptosis, on membrane integrity, on the immune function, on the estrogenic properties on the tissue and on acids and neutral steroids in the colon [31]....
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...Chemically, they are alcohols consisting of 28 or 29 carbon atoms, similar to cholesterol [31]....
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579 citations
"Estrogenic and mutagenic activities..." refers background in this paper
...Flavonoids have some structural similarities to the natural estrogen 17-β-estradiol, as well as to other steroid hormones and steroid hormone antagonists [26], and can interact with the ER and induce gene expression similar to that induced by estrogens, albeit at a lower affinity [27]....
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