Estrogenic terpenes and terpenoids: Pathways, functions and applications.
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110 citations
Cites background from "Estrogenic terpenes and terpenoids:..."
...The terpenoids have also application to cancer treatment, prevention, cardioprotection, endocrine toxicity/ reproductive dysfunction, food supplement, traditional medicine, immunology, inflammation, menopausal syndromes, and neuroprotection.([7])...
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References
3,599 citations
"Estrogenic terpenes and terpenoids:..." refers background in this paper
...Estrogen acts as an important hormone that moderates and regulates cell functions, such as growth, proliferation and apoptosis, and contributes to the maintenance and control of physiology, and behavior of humans and animals (Melmed et al., 2016)....
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...Estrogen acts as an important hormone that moderates and reg- ulates cell functions, such as growth, proliferation and apoptosis, and contributes to the maintenance and control of physiology, and behavior of humans and animals (Melmed et al., 2016)....
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2,091 citations
759 citations
"Estrogenic terpenes and terpenoids:..." refers background in this paper
...3-Benzylidene camphor (E) ERβ/Skin cancer Schlumpf et al. (2001) (A, C, P)...
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...…in vivo and in vitro assays for estrogenic activity presumably due to their ability to bind to ERs (preferentially to ERβ), although the possibility of metabolite activation or involvement of other receptors cannot not be excluded (Schlumpf et al., 2001; Tinwell et al., 2002; Klann et al., 2005)....
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...estrogenic according to in vivo and in vitro assays for estrogenic activity presumably due to their ability to bind to ERs (preferentially to ERβ), although the possibility of metabolite activation or involvement of other receptors cannot not be excluded (Schlumpf et al., 2001; Tinwell et al., 2002; Klann et al., 2005)....
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611 citations
"Estrogenic terpenes and terpenoids:..." refers background in this paper
..., 2005) and affect breast cancer prognosis (Migliaccio et al., 1998; Ballaré et al., 2006)....
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...Progestin (PR agonist) PR:ER/Src/Ras/ERK/Breast cancer B Migliaccio et al. (1998) (P)...
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...…agonist) binds to PR and modulates estrogen signaling pathways, such as Src/Ras/ERK and ERK/PI3K/Akt pathways, by receptor crosstalk, and was reported to contribute to reproductive regulation (Vallejo et al., 2005) and affect breast cancer prognosis (Migliaccio et al., 1998; Ballaré et al., 2006)....
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509 citations
"Estrogenic terpenes and terpenoids:..." refers background in this paper
...Retinoids (A) ER/Cancer treatment Tang and Gudas (2011) (review)...
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...Thus, retinoids have been studied as modulators of cancer-related signaling for prevention and treatment of breast, cervical and other hormone-related cancers (Dragnev et al., 2000; Gariglio et al., 2009; Tang and Gudas, 2011)....
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...Retinoids (vitamin A/retinol, retinal, retinoic acid and their derivatives) are cyclophytane diterpenes, and their structure consists of a cyclic end group (a β-ionone ring), a polyene side chain and a polar end group (Tang and Gudas, 2011)....
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