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Ethnopharmacology and drug discovery
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The list of compounds derived from such knowledge is very long indeed and includes morphine, codeine, and aspirin to name just a few but also drugs licensed relatively recently like galanthamine and artemisinine as mentioned in this paper.Abstract:
Drug discovery and development (very often unknowingly) is based on traditional and local knowledge about a species’ medical use or toxicological effects (both desired and undesired effects). The list of compounds ultimately derived from such knowledge is very long indeed and includes morphine, codeine, and aspirin to name just a few but also drugs licensed relatively recently like galanthamine and artemisinine. Here I review this link and – using examples of new drugs currently under development preclinically or in clinical trials – discuss how such new drugs have been ‘discovered’, or more precisely developed into a clinically used medication.read more
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References
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Journal ArticleDOI
Natural Products as Sources of New Drugs over the Period 1981−2002
TL;DR: From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well, and in the area of cancer, the percentage of small molecule, new chemical entities that are nonsynthetic has remained at 62% averaged over the whole time frame.
Journal ArticleDOI
The evolving role of natural products in drug discovery
Frank E. Koehn,Guy T. Carter +1 more
TL;DR: Recent technological advances that help to address issues such as the lack of compatibility of traditional natural-product extract libraries with high-throughput screening and unrealized expectations from current lead-generation strategies have led to a renewed interest in natural products in drug discovery.
Journal ArticleDOI
Drugs for bad bugs: confronting the challenges of antibacterial discovery
TL;DR: The experience of evaluating more than 300 genes and 70 high-throughput screening campaigns over a period of 7 years is shared, and what is learned is looked at and how that has influenced GlaxoSmithKline's antibacterials strategy going forward.
Journal ArticleDOI
Plants as a source of anti-cancer agents.
Gordon M. Cragg,David J. Newman +1 more
TL;DR: A number of promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and combretastin A4 phosphate, while some agents which failed in earlier clinical studies are stimulating renewed interest.