Journal ArticleDOI
Etiology of inguinal hernia: ultrastructure of rectus sheath revisited.
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TLDR
The theory linking connective tissue alterations with the etiology of hernia, and stating that these alterations include connectives tissue at locations distant from the hernia site as well, is supported, as the rectus sheath itself does not form a hernial defect.Abstract:
In the last decade, in the search for abdominal-wall hernia etiology, attention has been brought to alterations in the connective tissue ultrastructure as the probable etiological factor. These may cause weakening of connective tissue, which in turn may form ground for hernia formation. To investigate this hypothesis in depth, we compared the ultrastructure of the connective tissue in hernia patients and the control group. The study group consisted of five patients with primary inguinal hernia (Nyhus II = 4, Nyhus IIIa = 1). Another five patients posted for emergency appendectomy created the control group. Tissue specimens, harvested intraoperatively from the rectus muscle sheath (RAMS) and fixed in 4% glutaraldehyde, underwent staining by the Masson, H-E and methylene blue techniques and were assessed by microscopy (light and scanning electron). The examinations showed significant differences in the rectus sheath ultrastructure. They included altered architecture, placement and quantity of collagen and elastic fibers, differences in the caliber of individual fibers and disrupted ground matter-to-fiber ratio. In patients with hernias, chaotic arrangement of collagen fibers was seen, as well as their thinning and a decrease in the general amount of elastic fibers, replaced by ground matter. Our research has shown significant differences in the structure of the RAMS between patients with hernias and healthy individuals. This supports the theory linking connective tissue alterations with the etiology of hernia, and stating that these alterations include connective tissue at locations distant from the hernia site as well, as the rectus sheath itself does not form a hernial defect.read more
Citations
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Connective tissue alteration in abdominal wall hernia
TL;DR: The aim of this study was to review the literature on specific collagen alterations in abdominal wall hernia formation to assess the need for further research into these mechanisms.
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Inguinal hernia in the 21st century: an evidence-based review.
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The Inguinal Canal: Anatomy and Imaging Features of Common and Uncommon Masses
TL;DR: A combination of the clinical history, symptoms, laboratory values, and radiologic features aids the radiologist in accurately diagnosing mass lesions of the inguinal canal.
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Etiology of Inguinal Hernias: A Comprehensive Review
TL;DR: The aim was to summarize the evidence on hernia etiology, with focus on differences between lateral and medial hernias, and identify genes that have been identified that also are involved in connective tissue homeostasis.
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Posterior polymorphous corneal dystrophy is associated with TCF8 gene mutations and abdominal hernia
Anthony J. Aldave,Vivek S. Yellore,Fei Yu,Nirit Bourla,Baris Sonmez,Andrew K. Salem,Sylvia A. Rayner,Kapil M. Sampat,Charles M. Krafchak,Julia E. Richards +9 more
TL;DR: In this paper, the two-handed zinc-finger homeodomain transcription factor gene (TCF8) has been associated with posterior polymorphous corneal dystrophy (PPCD) and extraocular developmental abnormalities.
References
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Journal ArticleDOI
Factors Affecting Recurrence following Incisional Herniorrhaphy
Thomas Anthony,Patricia C. Bergen,Lawrence T. Kim,Mark C. Henderson,Thomas J. Fahey,Robert V. Rege,Richard H. Turnage +6 more
TL;DR: The percent ideal body weight and BMI of patients who developed a recurrent hernia, particularly following a prosthetic repair, were significantly greater than those of patients whose repairs remained intact.
Journal ArticleDOI
Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene.
Alain Colige,Aleksander Sieroń,Shi-Wu Li,Ulrike Schwarze,Elizabeth M. Petty,Wladimir Wertelecki,William R. Wilcox,Deborah Krakow,Daniel H. Cohn,W. Reardon,Peter H. Byers,Charles M. Lapière,Darwin J. Prockop,Betty Nusgens +13 more
TL;DR: The mutations that cause Ehlers-Danlos syndrome type VIIC are identified in the six known affected human individuals and also in one strain of dermatosparactic calf and used bovine cDNA to isolate human pNPI.
Journal ArticleDOI
Einflussfaktoren der Narbenhernienentstehung Retrospektive Untersuchung an 2.983 laparotomierten Patienten über einen Zeitraum von 10 Jahren
TL;DR: The calculated incisional hernia incidence for a 10 year period of almost 20% and the manifestation of 50% of all hernias more than 12 months after the operation, underline the necessity to intensify surgical research in the field of laparotomy healing.
Journal ArticleDOI
[Factors influencing the development of incisional hernia. A retrospective study of 2,983 laparotomy patients over a period of 10 years].
TL;DR: In this article, the influence of demographic data, pre-, intra-and post-operative risk factors for incisional hernia development were evaluated in a retrospective study including 2983 patients over a 10-year period.