scispace - formally typeset
Search or ask a question
Journal Article•DOI•

European experts consensus statement on cystic tumours of the pancreas.

Marco Del Chiaro1, Caroline S. Verbeke1, Roberto Salvia2, Günter Klöppel3, Jens Werner4, Colin J. McKay5, Helmut Friess6, Riccardo Manfredi2, Eric Van Cutsem7, Matthias Löhr1, Ralf Segersvärd1, L. Abakken8, Mustapha Adham9, N. Albin1, Å. Andrén-Sandberg1, Urban Arnelo1, Marco J. Bruno10, Djuna L. Cahen10, Carla Cappelli11, Guido Costamagna12, M Del Chiaro1, G. Delle Fave13, Irene Esposito6, Massimo Falconi14, Helmut Friess6, Paula Ghaneh15, I. P. Gladhaug8, Stephan L. Haas1, Truls Hauge8, Jakob R. Izbicki16, Günther Klöppel3, Markus M. Lerch, Lars Lundell1, Jutta Lüttges, M. Löhr1, R. Manfredi2, Julia Mayerle, C. McKay5, Kofi Oppong17, Aldis Pukitis, Elena Rangelova1, Thomas Rösch16, Roberto Salvia2, Richard D. Schulick18, R. Segersvärd1, T. Sufferlein19, E. Van Cutsem7, S. van der Merwe7, C. Verbeke1, J. Werner4, Giuseppe Zamboni2 •
Karolinska Institutet1, University of Verona2, University of Kiel3, Heidelberg University4, Glasgow Royal Infirmary5, Technische Universität München6, Katholieke Universiteit Leuven7, University of Oslo8, University of Lyon9, Erasmus University Rotterdam10, University of Pisa11, Catholic University of the Sacred Heart12, Sapienza University of Rome13, Marche Polytechnic University14, University of Liverpool15, University of Hamburg16, Freeman Hospital17, University of Colorado Boulder18, University of Ulm19
01 Sep 2013-Digestive and Liver Disease (Elsevier)-Vol. 45, Iss: 9, pp 703-711
TL;DR: Diagnostic computerized tomography and/or magnetic resonance imaging are indicated in all patients with cystic lesion of the pancreas and in lesions with a suspicion of malignancy, otherwise organ preserving procedures may be considered.
About: This article is published in Digestive and Liver Disease.The article was published on 2013-09-01. It has received 411 citations till now. The article focuses on the topics: Intraductal papillary mucinous neoplasm & Cystic Neoplasm.
Citations
More filters
Journal Article•DOI•
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.

[...]

Masao Tanaka, Carlos Fernandez-del Castillo1, Terumi Kamisawa, Jin-Young Jang2, Philippe Lévy, Takao Ohtsuka3, Roberto Salvia4, Yasuhiro Shimizu, Minoru Tada5, Christopher L. Wolfgang6 •
Harvard University1, New Generation University College2, Kyushu University3, University of Verona4, University of Tokyo5, Johns Hopkins University6
01 Sep 2017-Pancreatology
TL;DR: The working group has revised the guidelines regarding prediction of invasive carcinoma and high-grade dysplasia, surveillance, and postoperative follow-up of IPMN and includes updated information and recommendations based on the current understanding.

1,104 citations

Journal Article•DOI•
European evidence-based guidelines on pancreatic cystic neoplasms

[...]

Marco Del Chiaro, Marc G. Besselink1, Lianne Scholten, Marco J. Bruno, Djuna L. Cahen, Thomas M. Gress, Jeanin E. van Hooft, Markus M. Lerch, Julia Mayerle, Thilo Hackert, Sohei Satoi, Alessandro Zerbi, David Cunningham, Claudio De Angelis, Marc Giovanni, Enrique de-Madaria, Péter Hegyi, Jonas Rosendahl, Helmut Friess, Riccardo Manfredi, Philippe Lévy, Francisco X. Real, Alain Sauvanet, Mohammed Abu Hilal, Giovanni Marchegiani, Irene Esposito, Paula Ghaneh, Marc R. W. Engelbrecht, Paul Fockens, Nadine C.M. van Huijgevoort, Christopher L. Wolfgang, Claudio Bassi, Natalya Gubergrits, Caroline S. Verbeke, Günter Klöppel, Aldo Scarpa, Giuseppe Zamboni, Anne Marie Lennon, Malin Sund, Nikolaos Kartalis, Lars Grenacher, Massimo Falconi1, Urban Arnelo, Kostantin V. Kopchak, Kofi Oppong, Colin J. McKay, Truls Hauge, Kevin C. Conlon, Mustapha Adham, Güralp O. Ceyhan, Roberto Salvia, Christos Dervenis, Peter J. Allen, François Paye, Detlef K. Bartsch, Matthias Löhr, Massimiliano Mutignani, Johanna Laukkarinen, Richard D. Schulick, Roberto Valente, Thomas Seufferlein, Gabriele Capurso, Ajith K. Siriwardena, John P. Neoptolemos, Aldis Pukitis, Ralf Segersvärd, Ali A. Aghdassi, Stefano Andrianello, Peter Bossuyt, Robin Bülow, Karina Cárdenas-Jaén, P. Cortegoso, Martina Fontana, Lena Haeberle, M. Heckler, Andrey Litvin, Kulbir Mann, Christoph W. Michalski, Patrick Michl, Gennaro Nappo, Giampaolo Perri, S. Persson, F. Scheufele, Francesco Sclafani, Manuel Schmidt, L. Venezia, F. Volker, M-P Vullierm, L. Wusten •
Vita-Salute San Raffaele University1
01 May 2018-Gut
TL;DR: A conservative approach is recommended for asymptomatic MCN and IPMN, and Lifelong follow-up of IPMN is recommended in patients who are fit for surgery.
Abstract: Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy. It replaces the 2013 European consensus statement guidelines on PCN. European and non-European experts performed systematic reviews and used GRADE methodology to answer relevant clinical questions on nine topics (biomarkers, radiology, endoscopy, intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm (MCN), serous cystic neoplasm, rare cysts, (neo)adjuvant treatment, and pathology). Recommendations include conservative management, relative and absolute indications for surgery. A conservative approach is recommended for asymptomatic MCN and IPMN measuring 5 mm, and MPD diameter >10 mm. Lifelong follow-up of IPMN is recommended in patients who are fit for surgery. The European evidence-based guidelines on PCN aim to improve the diagnosis and management of PCN.

712 citations

Journal Article•DOI•
Pancreatic adenocarcinoma, Version 2.2021

[...]

Margaret A. Tempero1, Mokenge P. Malafa2, Mahmoud M. Al-Hawary3, Stephen W. Behrman4, Al B. Benson5, Dana Backlund Cardin6, E. Gabriela Chiorean7, Vincent Chung8, Brian G. Czito9, Marco Del Chiaro10, Mary Dillhoff11, Timothy R. Donahue12, Efrat Dotan13, Cristina R. Ferrone14, Christos Fountzilas15, Jeffrey M. Hardacre16, William G. Hawkins17, Kelsey Klute18, Andrew H. Ko1, John W. Kunstman19, Noelle K. LoConte20, Andrew M. Lowy21, Cassadie Moravek22, Eric K. Nakakura1, Amol Narang23, Jorge Obando9, Patricio M. Polanco24, Sushanth Reddy25, Marsha Reyngold26, Courtney L. Scaife27, Jeanne Shen28, Charles M. Vollmer29, Robert A. Wolff30, Brian M. Wolpin31, Beth Lynn32, Giby V. George32 •
University of California, San Francisco1, University of South Florida2, University of Michigan3, University of Tennessee Health Science Center4, Northwestern University5, Vanderbilt University6, Seattle Cancer Care Alliance7, City of Hope National Medical Center8, Duke University9, University of Colorado Boulder10, Ohio State University11, University of California, Los Angeles12, Fox Chase Cancer Center13, Harvard University14, Roswell Park Cancer Institute15, Case Western Reserve University16, Washington University in St. Louis17, University of Nebraska Medical Center18, Yale Cancer Center19, University of Wisconsin-Madison20, University of California, San Diego21, Pancreatic Cancer Action Network22, Johns Hopkins University23, University of Texas Southwestern Medical Center24, University of Alabama at Birmingham25, Memorial Sloan Kettering Cancer Center26, University of Utah27, Stanford University28, University of Pennsylvania29, University of Texas MD Anderson Cancer Center30, Brigham and Women's Hospital31, National Comprehensive Cancer Network32
01 Apr 2021-Journal of The National Comprehensive Cancer Network
Abstract: Pancreatic cancer is the fourth leading cause of cancer-related death among men and women in the United States. A major challenge in treatment remains patients' advanced disease at diagnosis. The NCCN Guidelines for Pancreatic Adenocarcinoma provides recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with pancreatic cancer. Although survival rates remain relatively unchanged, newer modalities of treatment, including targeted therapies, provide hope for improving patient outcomes. Sections of the manuscript have been updated to be concordant with the most recent update to the guidelines. This manuscript focuses on the available systemic therapy approaches, specifically the treatment options for locally advanced and metastatic disease.

402 citations

Journal Article•DOI•
ACG Clinical Guideline: Diagnosis and Management of Pancreatic Cysts

[...]

Grace H. Elta1, Brintha K. Enestvedt2, Bryan G. Sauer3, Anne Marie Lennon4•
University of Michigan1, Oregon Health & Science University2, University of Virginia3, Johns Hopkins University4
27 Feb 2018-The American Journal of Gastroenterology
TL;DR: This guideline will provide a practical approach to pancreatic cyst management and recommendations for cyst surveillance for the general gastroenterologist.

389 citations

Journal Article•DOI•
American Gastroenterological Association Technical Review on the Diagnosis and Management of Asymptomatic Neoplastic Pancreatic Cysts

[...]

James M. Scheiman1, Joo Ha Hwang2, Paul Moayyedi3•
University of Michigan1, University of Washington2, McMaster University3
01 Apr 2015-Gastroenterology
TL;DR: The challenges in evaluating pancreatic cysts are discussed, a rational, evidence-based, cost-effective approach to care of the patient with a pancreas remains poorly defined and the existing data set is critically examined.

337 citations

References
More filters
Book•DOI•
TNM classification of malignant tumours

[...]

Leslie H. Sobin, Mary Gospodarowicz, Ch. Wittekind
01 Jan 1987
TL;DR: Head and Neck Tumours.- Lip and Oral Cavity.- Pharynx.- Larynx.' Maxillary Sinus.- Salivary Glands.- Thyroid Gland.- Digestive System Tumour .
Abstract: Head and Neck Tumours.- Lip and Oral Cavity.- Pharynx.- Larynx.- Maxillary Sinus.- Salivary Glands.- Thyroid Gland.- Digestive System Tumours.- Oesophagus.- Stomach.- Colon and Rectum.- Anal Canal.- Liver.- Gall Bladder.- Extrahepatic Bile Ducts.- Ampulla of Vater.- Pancreas.- Lung Tumours.- Tumours of Bone and Soft Tissues.- Bone.- Soft Tissue.- Skin Tumours.- Carcinoma of Skin.- Melanoma of Skin.- Breast Tumours.- Gynaecological Tumours.- Cervix Uteri.- Corpus Uteri.- Ovary.- Vagina.- Vulva.- Urological Tumours.- Prostate.- Testis.- Penis.- Urinary Bladder.- Kidney.- Renal Pelvis and Ureter.- Urethra.- Ophthalmic Tumours.- Carcinoma of Eyelid.- Malignant Melanoma of Eyelid.- Carcinoma of Conjunctiva.- Malignant Melanoma of Conjunctiva.- Malignant Melanoma of Uvea.- Retinoblastoma.- Sarcoma of Orbit.- Carcinoma of Lacrimal Gland.- Brain Tumours.- Hodgkin's Disease.- Non-Hodgkin's Lymphoma.- Paediatric Tumours.- Nephroblastoma (Wilms' Tumour).- Neuroblastoma.- Soft Tissue Sarcomas - Paediatric.

15,624 citations

Book•
WHO Classification of Tumours of the Digestive System

[...]

Fred T. Bosman
01 Jan 2010
TL;DR: WHO Classification of Tumours of the Digestive System - Libros de Medicina - Gastroenterologia oncologica - 128,25
Abstract: WHO Classification of Tumours of the Digestive System - Libros de Medicina - Gastroenterologia oncologica - 128,25

4,643 citations

"European experts consensus statemen..." refers background or methods in this paper

  • ...The classification outlined n Table 2 is in accordance with the WHO 2010 classification of ancreatic tumours [10]....

    [...]

  • ...Morphological eatures of the four types along with differences in immunohistohemical staining for mucins and CDX-2, have been characterized n detail [10,116,117]....

    [...]

  • ...Depending on local expertise, horizontal slicing of the specimen along the plane of a probe inserted in the main pancreatic duct may also be performed [10]....

    [...]

  • ...In some cases of MCN, extensive sampling will be necessary for the identification of ovarian-type stroma, which is a diagnostic requirement for this tumour entity, or to visualize the neoplastic epithelial lining, which due to regressive change is not uncommonly largely absent [10]....

    [...]

  • ...The presence of invasive carcinoma in assoiation with IPMN or MCN is the main determinant of outcome, nd the usual descriptors of invasive carcinoma should be recorded, hat is histological tumour type (tubular, colloid, oncocytic, or other ariants [10]), grade of differentiation, tumour size and tumour xtension....

    [...]

Journal Article•DOI•
International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas

[...]

Masao Tanaka1, Carlos Fernandez-del Castillo2, Volkan Adsay3, Suresh T. Chari4, Massimo Falconi, Jin-Young Jang5, Wataru Kimura6, Philippe Lévy, Martha B. Pitman2, C. Max Schmidt7, Michio Shimizu8, Christopher L. Wolfgang9, Koji Yamaguchi10, Kenji Yamao •
Kyushu University1, Harvard University2, Emory University3, Mayo Clinic4, Seoul National University5, Yamagata University6, Indiana University – Purdue University Indianapolis7, Saitama Medical University8, Johns Hopkins University9, University of Occupational and Environmental Health Japan10
01 May 2012-Pancreatology
TL;DR: The present guidelines include recent information and recommendations based on the current understanding, and highlight issues that remain controversial and areas where further research is required.

2,053 citations

"European experts consensus statemen..." refers background in this paper

  • ...Currently, guidelines dedicated only mucinous cystic neoplasms exist, while comprehensive guidance for the diagnosis and management of all cystic tumours of the pancreas are lacking [7,8]....

    [...]

Journal Article•DOI•
A validation study of the Hospital Anxiety and Depression Scale (HADS) in different groups of Dutch subjects

[...]

Ph. Spinhoven1, Johan Ormel2, P. P. A. Sloekers2, Gertrudis I. J. M. Kempen2, Anne E. M. Speckens2, A.M. van Hemert2 •
Leiden University1, University of Groningen2
01 Mar 1997-Psychological Medicine
TL;DR: The moderate PPV suggests that the HADS is best used as a screening questionnaire and not as a 'case-identifier' for psychiatric disorder or depression.
Abstract: Background. Research on the dimensional structure and reliability of the Hospital Anxiety and Depression Scale (HADS) and its relationship with age is scarce. Moreover, its ecacy in determining the presence of depression in dierent patient groups has been questioned. Methods. Psychometric properties of the HADS were assessed in six dierent groups of Dutch subjects (N fl 6165): (1) a random sample of younger adults (age 18‐65 years) (N fl 199); (2) a random sample of elderly subjects of 57 to 65 years of age (N fl 1901); (3) a random sample of elderly subjects of 66 years or older (N fl 3293); (4) a sample of consecutive general practice patients (N fl 112); (5) a sample of consecutive general medical out-patients with unexplained somatic symptoms (N fl 169); and (6) a sample of consecutive psychiatric out-patients (N fl 491). Results. Evidence for a two-factor solution corresponding to the original two subscales of the HADS was found, although anxiety and depression subscales were strongly correlated. Homogeneity and test‐retest reliability of the total scale and the subscales were good. The dimensional structure and reliability of the HADS was stable across medical settings and age groups. The correlations between HADS scores and age were small. The total HADS scale showed a better balance between sensitivity and positive predictive value (PPV) in identifying cases of psychiatric disorder as defined by the Present State Examination than the depression subscale in identifying cases of unipolar depression as defined by ICD-8. Conclusions. The moderate PPV suggests that the HADS is best used as a screening questionnaire and not as a ‘case-identifier’ for psychiatric disorder or depression.

1,955 citations

"European experts consensus statemen..." refers background in this paper

  • ... The perceived burden of surveillance for participants, as assessed by questionnaires regarding attitude towards surveillance and general anxiety and depression (Hospital Anxiety and Depression scale, HADS) (Table V) [15-19]....

    [...]

Journal Article•DOI•
International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas.

[...]

Masao Tanaka1, Suresh T. Chari2, Volkan Adsay3, Carlos Fernandez-del Castillo4, Massimo Falconi5, Michio Shimizu6, Koji Yamaguchi1, Kenji Yamao, Seiki Matsuno7 •
Kyushu University1, Mayo Clinic2, Wayne State University3, Harvard University4, Vita-Salute San Raffaele University5, Saitama Medical University6, Tohoku University7
01 Apr 2006-Pancreatology
TL;DR: Ovarian-type stroma has been proposed as a requisite to distinguish MCN from IPMN, and some other distinct features to characterize IPMN and MCN have been identified, but there remain ambiguities between the two diseases.

1,912 citations

"European experts consensus statemen..." refers background in this paper

  • ...Q11: Is the size of the cystic lesion an important criterion to suggest malignant transformation in BD-IPMN? The dimension of BD-IPMN was previously considered crucial for management decision making [7]....

    [...]

  • ...Q19: How should patients, who underwent resection for MCN, be followed-up? Patients with benign MCNs do not need to be followed-up, since several studies have shown zero recurrence after complete resection [7,65,71]....

    [...]

  • ...Currently, guidelines dedicated only mucinous cystic neoplasms exist, while comprehensive guidance for the diagnosis and management of all cystic tumours of the pancreas are lacking [7,8]....

    [...]

  • ...Q14: How should BD-IPMN be resected? If malignancy cannot be excluded, an oncological resection hould be undertaken [7,11]....

    [...]

Related Papers (5)
International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas

[...]

01 May 2012-Pancreatology
Masao Tanaka, Carlos Fernandez-del Castillo, Volkan Adsay, Suresh T. Chari, Massimo Falconi, Jin-Young Jang, Wataru Kimura, Philippe Lévy, Martha B. Pitman, C. Max Schmidt, Michio Shimizu, Christopher L. Wolfgang, Koji Yamaguchi, Kenji Yamao 
American gastroenterological association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts.

[...]

01 Apr 2015-Gastroenterology
Santhi Swaroop Vege, Barry Ziring, Rajeev Jain, Paul Moayyedi, Megan A. Adams, Spencer D. Dorn, Sharon Dudley-Brown, Steven L. Flamm, Ziad F. Gellad, Claudia B. Gruss, Lawrence R. Kosinski, Joseph K. Lim, Yvonne Romero, Joel H. Rubenstein, Walter E. Smalley, Shahnaz Sultan, David S. Weinberg, Yu-Xiao Yang 
International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas.

[...]

01 Apr 2006-Pancreatology
Masao Tanaka, Suresh T. Chari, Volkan Adsay, Carlos Fernandez-del Castillo, Massimo Falconi, Michio Shimizu, Koji Yamaguchi, Kenji Yamao, Seiki Matsuno 
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.

[...]

01 Sep 2017-Pancreatology
Masao Tanaka, Carlos Fernandez-del Castillo, Terumi Kamisawa, Jin-Young Jang, Philippe Lévy, Takao Ohtsuka, Roberto Salvia, Yasuhiro Shimizu, Minoru Tada, Christopher L. Wolfgang 
Prevalence of Unsuspected Pancreatic Cysts on MDCT

[...]

01 Sep 2008-American Journal of Roentgenology
Thomas A. Laffan, Karen M. Horton, Alison P. Klein, Bruce Berlanstein, Stanley S. Siegelman, Satomi Kawamoto, Pamela T. Johnson, Elliot K. Fishman, Ralph H. Hruban