Journal ArticleDOI
Evaluation of dietary arsenic exposure and its biomarkers: a case study of West Bengal, India
Debendra Nath Guha Mazumder,Debasree Deb,Anirban Biswas,Chandan Saha,Ashoke Kumar Nandy,Bhaswati Ganguly,Aloke Ghose,K. Bhattacharya,Kunal Kanti Majumdar +8 more
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TLDR
Those with skin lesions were found to have higher arsenic in urine and hair compared to those without skin lesion with similar arsenic intake through water and diet, while these values were low in people living in non-endemic region (Group-2).Abstract:
Few reports are available that characterize daily arsenic exposure through water and diet among people living in groundwater-contaminated regions and correlate it with biomarkers. The present study describes the total individual arsenic exposure and arsenic level in urine and hair of such an arsenic-exposed population in West Bengal. Demographic characteristics and the total daily arsenic intake through water and diet were determined in 167 (Group-1 participants selected from arsenic endemic region) and 69 (Group-2 participants selected from arsenic non-endemic region) in West Bengal. Out of 167 Group-1 participants 78 (Group-1A) had arsenical skin lesions while 89 Group-1B) had no such lesion. Arsenic level in water samples as well as diet, urine and hair samples, collected from all the individual participants, were estimated. The mean value of estimated total arsenic content from water and diet was 349 (range: 20-1615) μg/day in 167 (Group-1) participants living in As endemic region [As in water: mean value 54 (range:BDL-326) μg/L] and 36 (range:12-120) μg/day in 69 (Group-2) participants living in As non-endemic region (As in water: below detection level (BDL), < 0.3 μg/L). Estimated mean arsenic level in urine in these two groups of participants was 116 (range: 6-526) μg/L and 17 (range: BDL-37) μg/L and in hair was 1.0 (range: 0.22-3.98) mg/Kg and 0.16 (range: 0.06-0.37) mg/Kg, respectively. Multiple regressions analysis in Group-1 participants showed that total arsenic intake was associated significantly with urinary and hair arsenic level. The estimated regression coefficient was 0.0022 (95% confidence interval, C.I: 0.0016, 0.0028; P < 0.001) and 0.0024 (95% C.I: 0.0021, 0.003; P < 0.001), respectively. In sub group analysis, higher median urinary arsenic value relative to arsenic intake through water and diet was observed in 78 Group-1A subjects with skin lesion compared to urinary arsenic value in 89 Group-1B subjects without skin lesions, though there was a marginal difference of median total arsenic intake in these two groups. This study showed that significant elevation of arsenic level in urine and hair was associated with elevated arsenic intake through water and diet in people living in arsenic endemic region (Group-1), while these values were low in people living in non-endemic region (Group-2). Those with skin lesions were found to have higher arsenic in urine and hair compared to those without skin lesion with similar arsenic intake through water and diet.read more
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Journal ArticleDOI
Arsenic in groundwater of West Bengal, India: A review of human health risks and assessment of possible intervention options.
Subhamoy Bhowmick,Sreemanta Pramanik,Payel Singh,Priyanka Mondal,Debashis Chatterjee,Jerome O. Nriagu +5 more
TL;DR: Comparing and contrast the similarities and differences in arsenic occurrence in West Bengal with those of other parts of the world and assess the unique socio-cultural factors that determine the risks of exposure to arsenic in local groundwater are compared.
Journal ArticleDOI
Inorganic arsenic: A non-genotoxic carcinogen.
TL;DR: The data strongly supports a non-linear dose response for the effects of inorganic arsenic, and in various in vitro and in vivo models and in human epidemiology studies there appears to be a threshold for biological responses, including cancer.
Journal ArticleDOI
Human health risk assessment for arsenic: A critical review
TL;DR: An up-to-date review of the different sources of arsenic, indicators of human exposure, epidemiological and toxicological studies on carcinogenic and noncarcinogenic health outcomes, and risk assessment approaches demonstrates a need for more work evaluating the risks of different arsenic species.
Journal ArticleDOI
Safe limit of arsenic in soil in relation to dietary exposure of arsenicosis patients from Malda district, West Bengal- A case study
Debasis Golui,D.N. Guha Mazumder,S.K. Sanyal,Siba Prasad Datta,P. Ray,P. K. Patra,S. Sarkar,K. Bhattacharya +7 more
TL;DR: Toxic limit of extractable As in soil for rice in relation to soil properties and human health hazard, associated with consumption of rice grain by human, was established.
Journal ArticleDOI
Heavy metal contamination, major ion chemistry and appraisal of the groundwater status in coastal aquifer, Kalpakkam, Tamil Nadu, India
TL;DR: A total of 228 groundwater samples were collected at a depth of 10-30 feet below ground level (bgl) during one year period from nineteen wells around Kalpakkam, Tamil Nadu, India which is known for nuclear installations as discussed by the authors.
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TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
Journal ArticleDOI
Arsenic contamination of Bangladesh paddy field soils: implications for rice contribution to arsenic consumption.
Andrew A. Meharg,M.m. Rahman +1 more
TL;DR: Assessment of arsenic levels in paddy soils throughout Bangladesh showed that arsenic levels were elevated in zones where arsenic in groundwater used for irrigation was high, and where these tube-wells have been in operation for the longest period of time.
Some drinking-water disinfectants and contaminants, including arsenic
W. M Anders,Richard J. Bull,Kenneth P. Cantor,Dipankar Chakraborti,C. Chen,A. B. DeAngelo,David M. DeMarini,Catterina Ferreccio,S. Fukushima,T. W. Gebel,D. N. Mazumder,M. R. Karagas,Manolis Kogevinas,H. Komulainen,F. Le Curieux,Andrew A. Meharg,Jack C. Ng,Mark J. Nieuwenhuijsen,S. Olin,M. Pereira,Mohammad Mahmudur Rahman,J. A. Roberson +21 more
TL;DR: Members M.W. Anders, Richard J. Bull, Chien-Jen Chen, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, and Catterina Ferreccio.
Journal ArticleDOI
Variation in Arsenic Speciation and Concentration in Paddy Rice Related to Dietary Exposure
TL;DR: Pot experiments show that the proportions of DMAV in the grain are significantly dependent on rice cultivar (p = 0.026) and that plant nutrient status is effected by arsenic exposure.