Evaluation of Flavonoids as 2019-nCoV Cell Entry Inhibitor Through Molecular Docking and Pharmacological Analysis
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TLDR
In this article, the authors aimed at the receipt binding domain of S protein and ACE-2 receptor as promising drug targets against SARS-CoV-2 Flavonoids with anti-viral properties were taken as ligand for molecular docking Selected flavonoids showed extremely good pharmacokinetics properties with good absorption, solubility, metabolism, excretion, distribution, bioavailability and minimal toxicity.About:
This article is published in Heliyon.The article was published on 2021-03-01 and is currently open access. It has received 25 citations till now.read more
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Resolution of coronavirus disease 2019 (COVID-19).
Khaled Habas,Chioma Nganwuchu,Fanila Shahzad,Rajendran C. Gopalan,Mainul Haque,Sayeeda Rahman,Anwarul Azim Majumder,Talat Nasim +7 more
TL;DR: The bench to bedside translational research as well as reverse translational works focusing bedside to bench is very important and would provide the foundation for the development of targeted drugs and vaccines for COVID-19 infections.
Journal ArticleDOI
Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2.
Muchtaridi Muchtaridi,Muhammad Fauzi,Nur Kusaira Khairul Ikram,Amirah Mohd Gazzali,Habibah A. Wahab +4 more
TL;DR: This article summarizes the natural flavonoids with potential efficacy against COVID-19 through ACE2 receptor inhibition through angiotensin-converting enzyme inhibition activity.
Journal ArticleDOI
Molecular Basis of SARS-CoV-2 Infection and Rational Design of Potential Antiviral Agents: Modeling and Simulation Approaches.
Antonio Francés-Monerris,Cécilia Hognon,Tom Miclot,Tom Miclot,Cristina García-Iriepa,Isabel Iriepa,Alessio Terenzi,Stéphanie Grandemange,Giampaolo Barone,Marco Marazzi,Antonio Monari +10 more
TL;DR: This Review focuses on how in silico studies have contributed to the understanding of the SARS-CoV-2 infection mechanism and the proposal of novel and original agents to inhibit the viral key functioning, and demonstrates that molecular modeling and simulation represent an effective approach to gather information on key biological processes and thus guide rational molecular design strategies.
Journal ArticleDOI
Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2.
Arumugam Vijaya Anand,Balasubramanian Balamuralikrishnan,Mohandass Kaviya,Kathirvel Bharathi,Aluru Parithathvi,Meyyazhagan Arun,N. Senthilkumar,Shanmugam Velayuthaprabhu,Muthukrishnan Saradhadevi,Naif Abdullah Al-Dhabi,Mariadhas Valan Arasu,Mariadhas Valan Arasu,Mohammad Iqbal Yatoo,Ruchi Tiwari,Kuldeep Dhama +14 more
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Flavonoids as Promising Antiviral Agents against SARS-CoV-2 Infection: A Mechanistic Review.
TL;DR: In this article, a comprehensive review of the benefits of flavonoids in COVID-19 disease was provided, where five RNA viruses with similar clinical manifestations and/or pharmacological treatments, including influenza, human immunodeficiency virus (HIV), severe acute respiratory syndrome (SARS), MERS, and Ebola, were considered.
References
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