Evaluation of In vitro Anti-Diabetic and Anti-Oxidant activities and Preliminary Phytochemical screening of Gel, Epidermis and Flower extract of Aloe vera
30 Apr 2019-Research Journal of Pharmacy and Technology (Research Journal of Pharmacy and Technology)-Vol. 12, Iss: 4, pp 1761-1768
About: This article is published in Research Journal of Pharmacy and Technology.The article was published on 2019-04-30. It has received 15 citations till now. The article focuses on the topics: Aloe vera & Epidermis (botany).
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TL;DR: Wang et al. as mentioned in this paper investigated the synergistic effect of A. vera flower and Aloe gel in cutaneous wound healing, cell viability, and cell migration, as well proliferation assay was performed.
11 citations
TL;DR: This review presents an overview of the bioactive components of the Aloe genus with emphasis on their anti-diabetic potential and other pharmacological benefits, and the potential applications and constraints have been discussed.
Abstract: The therapeutic and pharmacological properties of plant bioactive constituents still continue to be the subject of many researches. Species of the Aloe genus have a history in folklore medicine and they have gained more attention over the years due to their various medicinal properties. Phytochemical studies have revealed that the Aloe species contain a number of constituents, such as polyphenols, phytosterols, polysaccharides, proteins, amino acids, chromones, and mineral elements. A comprehensive evidence-based review on the different constituents of Aloe species is needed in order to understand the benefits imparted by them. This review presents an overview of the bioactive components of the Aloe genus with emphasis on their anti-diabetic potential and other pharmacological benefits. This information will be beneficial for the advancement of new strategies of Aloe formulations with therapeutic and economical value in the near future. Furthermore, the potential applications and constraints have also been discussed so as to provide a wider prospect for research in this field for the benefit of the society.
11 citations
Cites background from "Evaluation of In vitro Anti-Diabeti..."
...The flower grows around 90 cm, often being pendulous and consists of yellow tubular corolla around 2–3 cm (Babu et al., 2019)....
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...Apart from that, polyphenols from Aloe species have been reported to possess anti-diabetic potential, anti-inflammatory properties, and wound healing properties (Babu et al., 2019)....
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TL;DR: In this paper, the antidiabetic effect of Aloe vera carbohydrate fraction (AVCF) was evaluated using α-amylase, α-glucosidase inhibition, glucose diffusion and glucose uptake assay.
9 citations
TL;DR: In this article , the synthesis of microspheres of Piper betle polyphenols by extrusion method using alginate and assesses the impact of alginates encapsulation on stability, bioavailability and therapeutic properties.
Abstract: Plant polyphenols have recently gained attention in nutraceutical and pharmaceutical industries due to their various therapeutic potentials. However, the polyphenols are prone to oxidation, unstable towards heat, light, pH and their unpleasant taste also limits their application. The usage of encapsulated polyphenols can alleviate these drawbacks and hence, efficient encapsulation methods have been developed. The present study focused on the synthesis of microspheres of Piper betle polyphenols by extrusion method using alginate and assesses the impact of alginate encapsulation on stability, bioavailability and therapeutic properties. Microspheres of Piper betle were studied for their stability, yield, size, characterized by using SEM for surface morphology and FTIR and evaluated for their bioavailability using in vitro simulated gastrointestinal digestion and therapeutic properties for a period of 24 months. The results showed that encapsulation was successful using extrusion technique and the stability was improved as it protected the polyphenols and antioxidant from degradation for a period of 24 months. In addition, bioavailability was also increased in small intestine and the antioxidant and antidiabetic properties were better retained after encapsulation. Overall, this study showed that encapsulation of polyphenols of Piper betle leaves with alginate improved stability and can be a promising technique for food supplementation/nutraceutical with natural antioxidants. • Polyphenols extracted from Piper betle were encapsulated in Alginate by extrusion method. • Polyphenols' bioavailability was increased in small intestine after encapsulation. • Alginate encapsulation helps in maintaining stability of polyphenols. • Polyphenol content was maintained for 24 months after encapsulation. • Anti-oxidant and anti-diabetic potential were maintained for 24 months.
3 citations
TL;DR: A review on the biological activities of some plant products used as complementary and alternative medicines in the management of metabolic syndromes, and on their reported antiviral, antithrombotic, angiotensin-converting enzyme inhibitory properties, which are integral to their usage in management of viral infections and may give an avenue for prophylactic and therapeutics especially in the absence of vaccines/formulated antiviral therapies as mentioned in this paper.
Abstract: The global market for medicinal plants and herbs is on the increase due to their desirability, efficacy, and less adverse effects as complementary and alternative medications to the orthodox pharmaceuticals, perhaps due to their natural components and qualities. Metabolic syndromes are managed with changes in diet, exercise, lifestyle modifications and the use of pharmacological agents. Plants are now known to have potent antioxidant and cholinergic activities which are relevant to the management of several metabolic syndromes, which are unfortunately, co-morbidity factors in the coronavirus disease crisis. This review will focus on the biological activities of some plant products used as complementary and alternative medicines in the management of metabolic syndromes, and on their reported antiviral, antithrombotic, angiotensin-converting enzyme inhibitory properties, which are integral to their usage in the management of viral infections and may give an avenue for prophylactic and therapeutics especially in the absence of vaccines/formulated antiviral therapies.
2 citations