Evaluation of reversible contraceptive potential of Cordia dichotoma leaves extract
01 Mar 2013-Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy (Sociedade Brasileira de Farmacognosia)-Vol. 23, Iss: 2, pp 342-350
TL;DR: The observations suggested that the developed phyto-pharmaceutical has potential antifertility activity with safety aspects and the reversible contraceptive potential after withdrawal.
Abstract: Considering the safety-risk ratio of steroidal contraceptives, the present work was carried out to evaluate ethno-contraceptive use of Cordia dichotoma G Forst, Boraginaceae, leaves (LCD) Preliminary pharmacological screening was performed on post-coital female albino rats The leaves extract (LD50 550 g/kg bw) showed 100% anti-implantation activity (n=10) at 800 mg/kg dose level (2-hydroxypropyl)-β-cyclodextrin (BCD) was used as bioavailability enhancer to form LCD-BCD complex, characterized by DLS, SEM and XRD analyses The LCD-BCD complex (1:1, w/w) exhibited 100% pregnancy interception (n=20) at the dose level of 250 mg/kg and also showed strong estrogenic potential with a luteal phase defect Qualitative and quantitative phytochemical analyses were carried out The LCD extract was standardized by a validated HPTLC method and two contraceptive phytoconstituents, apigenin and luteolin were isolated A detailed pharmacological analyses followed by chronic toxicity study were performed to predict the reversible nature of the developed phytopharmaceutical The histological and biochemical estimations detected the reversible contraceptive potential after withdrawal The observations suggested that the developed phyto-pharmaceutical has potential antifertility activity with safety aspects
Citations
More filters
TL;DR: The aim of this review was to provide exhaustive scientific information on traditional uses, phytochemistry and pharmacological activities of the 36 important species with medicinal value from the genus Cordia to divulge prospects for further research on its therapeutic potential.
Abstract: Objectives
Cordia (family Boraginaceae) is a genus of deciduous flowering trees or shrubs comprising more than 300 species distributed widely in the tropical regions. The aim of this review was to provide exhaustive scientific information on traditional uses, phytochemistry and pharmacological activities of the 36 important species with medicinal value from the genus Cordia, to divulge prospects for further research on its therapeutic potential.
Key findings
Leaves, fruit, bark and seed of a majority of the species were found to possess abundant ethnomedicinal value, but leaves were found to be used most frequently to treat many ailments such as respiratory disorders, stomach pain, wound, inflammation, myalgia, cough, dysentery and diarrhoea. The phytochemical investigation of 36 species resulted in isolation of 293 chemical constituents from various chemical classes. The crude extracts, fractions, essential oils and pure compounds isolated from various Cordia species were reported to have a varied range of pharmacological activities.
Summary
Many of the traditional uses of the genus Cordia were supported by the results obtained from pharmacological studies performed using various extracts or pure compounds. More attention should be given to the biological evaluation using pure phytochemicals and to identify the mechanism of actions and exploring this genus for new drug discovery.
67 citations
Cites background from "Evaluation of reversible contracept..."
...5 g/kg after oral administration.([202]) The hydroalcoholic leaf extract of C....
[...]
TL;DR: The principal botanical aspects, ethnopharmacological information and evaluation of the bioactive and pharmacological properties of Cordia, its phytochemical constituents and the most common classes of secondary metabolites identified are described.
Abstract: Species of the genus Cordia, Boraginaceae, are widely studied with regard to the various ethnobotanical and ethnopharmacological aspects. They are found principally in tropical and subtropical regions of the American, Asian and African continents, where they occur in various countries. In the genus Cordia, there are many species cultivated for ornamental plants, wood and medicinal applications, where they are extensively utilized by traditional communities. In the last decades, scientific studies of Cordia species have intensified, demonstrating the great interest in phytochemical, biological and pharmacological studies. In this review, we describe the principal botanical aspects, ethnopharmacological information and evaluation of the bioactive and pharmacological properties of Cordia, its phytochemical constituents and the most common classes of secondary metabolites identified. The information reported in this work contributes scientifically to recognizing the importance of the genus Cordia as a target in the search for new biotechnological investments.
43 citations
01 Jan 2015
TL;DR: In this paper, the authors describe the principal botanical aspects, ethnopharmacological information and evaluation of the bioactive and pharmacological properties of Cordia, itsphytochemicalconstituents and the most common classes of secondary metabolites identified.
Abstract: Species of the genus Cordia, Boraginaceae, are widely studied with regard to the various ethnobotanicaland ethnopharmacological aspects. They are found principally in tropical and subtropical regions of theAmerican,AsianandAfricancontinents,wheretheyoccurinvariouscountries.InthegenusCordia,thereare many species cultivated for ornamental plants, wood and medicinal applications, where they areextensively utilized by traditional communities. In the last decades, scientific studies of Cordia specieshaveintensified,demonstratingthegreatinterestinphytochemical,biologicalandpharmacologicalstud-ies. In this review, we describe the principal botanical aspects, ethnopharmacological information andevaluation ofthebioactiveandpharmacologicalpropertiesofCordia,itsphytochemicalconstituentsandthe most common classes of secondary metabolites identified. The information reported in this workcontributes scientifically to recognizing the importance of the genus Cordia as a target in the search fornew biotechnological investments.© 2015 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.
30 citations
TL;DR: Findings suggest that BPL may improve meat quality through the regulation of estrogen biosynthesis and may be useful for the discovery of potential aromatase modulators from natural products.
Abstract: Broussonetia papyrifera leaves (BPL) as a traditional Chinese medicine are also used in livestock feed for stimulating reproduction, adipose tissue and muscle development; however, the mechanism of their action is still unknown. Through estrogen biosynthesis-guided fractionation in human ovarian granulosa-like KGN cells, five new phenolic glycosides, broussoside A–E(1–5), along with fifteen known dietary phenolic compounds, were isolated from the n-butanol extract of BPL, and their structures were elucidated on the basis of NMR spectra analysis and chemical evidence. New compounds 3, 4, 5 and the known compounds 9 and 10 were found to potently inhibit estrogen biosynthesis in KGN cells. In addition, compounds 9, 17, 18, and 20 showed strong antioxidant activity against ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt) and DPPH (1, 1′-diphenyl -2-picryl-hydrazyl radical) assays. These findings suggest that BPL may improve meat quality through the regulation of estrogen biosynthesis. Furthermore, they may be useful for the discovery of potential aromatase modulators from natural products. Finally, they could be considered as a new source for natural antioxidants.
23 citations
Cites background from "Evaluation of reversible contracept..."
...Fifteen known dietary phenolic compounds (Figure 3) were also isolated and identified as syringaresinol-49-O-b-D-glucoside (6) [25], p-coumaric acid (7) [26,27], apigenin (8) [28], luteolin (9) [28], poliothyrsoside (10) [29], pinoresinol-49-O-b-D-glucopyranoside (11) [30,31], flacourtin (12) [31], dihydrosyringin (13) [32],apigenin-7-O-b -D-glucoside (14) [33], chrysoriol-7-O-b-Dglucoside (15) [34], isovitexin (16) [35], luteoloside (17) [33], orientin (18) [36–38], vitexin (19) [35], isoorientin (20) [38,39] on the basis of comparison of their NMR data with those reported in the literature....
[...]
TL;DR: Piperolactam A (PL), a representative of the inchoate skeleton of aristolactAM chassis might be the source of safe and affordable antileishmanial agents for the cure of deadly Leishmania infections.
18 citations
Cites methods from "Evaluation of reversible contracept..."
...3 mm thickness) plate prepared in CAMAG TLC plate coater (Bhattacharya and Saha, 2013)....
[...]
...The hexane:ethyl acetate (50:50) fraction showed most prominent presence of alkaloids and was subjected to further purification by preparative TLC over silica gel (0.3 mm thickness) plate prepared in CAMAG TLC plate coater (Bhattacharya and Saha, 2013)....
[...]
References
More filters
TL;DR: Gallocatechins of green tea and curcuminoids of ginger are the presently favoured polyphenols for a possible future use in co-medication with antibiotics and standard anticancer drugs and the main targets were found to be COX 1+2, NF-κB, and membrane glycoproteins that belong to the ATP-binding cassette (ABC) transporter family.
420 citations
"Evaluation of reversible contracept..." refers background in this paper
...The results of the activation of a signal cascade can be due to signal amplifi cation, and is much greater than the summation of the single effects (Imming et al., 2006; Wagner & Ulrich-Merzenich, 2009)....
[...]
TL;DR: The effects of estrogen-progestin balance on low-density and high-density lipoproteins may underlie the increased incidence of stroke and myocardial infarction in women of childbearing age who take oral contraceptives.
Abstract: We studied 374 women taking oral contraceptives, 284 women taking estrogen preparations after menopause, and 1086 women taking no hormones, to determine the relation of plasma lipids and lipoprotein cholesterol concentrations to various types of estrogen/progestin formulations. Premenopausal women, using oral contraceptives containing a relatively low dose of estrogen combined with a medium or high dose of progestin (Norlestrin, Ovral, or Demulen) had a 24 per cent higher median concentration of low-density-lipoprotein cholesterol than did those not using hormones (P less than 0.05). Women using oral contraceptives that are high in estrogen and low in progestin (Enovid or Oracon) had significantly higher concentrations of high-density-lipoprotein cholesterol than did nonusers; those using Ovral, a low-estrogen and high-progestin formulation, had significantly lower levels of high-density-lipoprotein cholesterol. In postmenopausal women the use of estrogen was associated with concentrations of low-density-lipoprotein cholesterol that were 11 to 19 per cent below the levels in postmenopausal women who did not use hormones. The effects of estrogen-progestin balance on low-density and high-density lipoproteins may underlie the increased incidence of stroke and myocardial infarction in women of childbearing age who take oral contraceptives.
356 citations
"Evaluation of reversible contracept..." refers background in this paper
...%) confi rmed that LCD has favorable effect on lipid profi le and seems to be free of cardiovascular risk factors, unlike steroidal oral contraceptives (Wahl et al., 1983)....
[...]
...27%) confi rmed that LCD has favorable effect on lipid profi le and seems to be free of cardiovascular risk factors, unlike steroidal oral contraceptives (Wahl et al., 1983)....
[...]
TL;DR: The present study attempts to identify the evolution of technical standards in manufacturing and the regulatory guideline development for commercialization of herbal drugs.
319 citations
"Evaluation of reversible contracept..." refers background in this paper
...The contents of arsenic (Chattopadhyay et al., 1999), cadmium (Johnson et al., 2003) and lead (WHO, 1995) in LCD preparation were found to be lower than the permissible limits (<5 ppb) mentioned in US-FDA and AYUSH (Sahoo et al., 2010)....
[...]
..., 2003) and lead (WHO, 1995) in LCD preparation were found to be lower than the permissible limits (<5 ppb) mentioned in US-FDA and AYUSH (Sahoo et al., 2010)....
[...]
TL;DR: This nationwide, population-based, case–control study investigated the association between the use of oral contraceptives and the risk of myocardial infarction according to the type of progestagen included in third-generation and second-generation oral contraceptives, the dose of estrogen, and the presence or absence of prothrombotic mutations.
Abstract: Background An association between the use of oral contraceptives and the risk of myocardial infarction has been found in some, but not all, studies. We investigated this association, according to the type of progestagen included in third-generation (i.e., desogestrel or gestodene) and second-generation (i.e., levonorgestrel) oral contraceptives, the dose of estrogen, and the presence or absence of prothrombotic mutations. Methods In a nationwide, population-based, case–control study, we identified and enrolled 248 women 18 through 49 years of age who had had a first myocardial infarction between 1990 and 1995 and 925 control women who had not had a myocardial infarction and who were matched for age, calendar year of the index event, and area of residence. Subjects supplied information on oral-contraceptive use and major cardiovascular risk factors. An analysis for factor V Leiden and the G20210A mutation in the prothrombin gene was conducted in 217 patients and 763 controls. Results The odds ratio for myo...
293 citations