Evaluation of the association between the JAK2 46/1 haplotype and chronic myeloproliferative neoplasms in a Brazilian population
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"Evaluation of the association betwe..." refers background or methods or result in this paper
...Blood samples were also collected from 90 healthy individuals (blood donors from the Hemocentro Regional de Maringá) and used as controls, as the JAK2 V617F mutation is not found in healthy individuals (3-6,13,14)....
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...The JAK2 V617F mutation was identified in more than 95% of PV patients and in approximately half of the patients with ET and MF but was not observed in healthy individuals (2-6)....
[...]
...As shown in Table 1, the characteristics of the studied patients are very similar to those observed in the literature (2-5), which indicates the comparability of our data and supports the assertion that the presence of the G allele is a pivotal factor in the development of cMPN in our population....
[...]
...It was observed that the JAK2 V617F mutation could occur in a homozygous or heterozygous fashion in the affected hematopoietic cells (2-5)....
[...]
3,326 citations
"Evaluation of the association betwe..." refers background or methods or result in this paper
...Blood samples were also collected from 90 healthy individuals (blood donors from the Hemocentro Regional de Maringá) and used as controls, as the JAK2 V617F mutation is not found in healthy individuals (3-6,13,14)....
[...]
...The JAK2 V617F mutation was identified in more than 95% of PV patients and in approximately half of the patients with ET and MF but was not observed in healthy individuals (2-6)....
[...]
...As shown in Table 1, the characteristics of the studied patients are very similar to those observed in the literature (2-5), which indicates the comparability of our data and supports the assertion that the presence of the G allele is a pivotal factor in the development of cMPN in our population....
[...]
...It was observed that the JAK2 V617F mutation could occur in a homozygous or heterozygous fashion in the affected hematopoietic cells (2-5)....
[...]
3,326 citations
"Evaluation of the association betwe..." refers background or methods or result in this paper
...Blood samples were also collected from 90 healthy individuals (blood donors from the Hemocentro Regional de Maringá) and used as controls, as the JAK2 V617F mutation is not found in healthy individuals (3-6,13,14)....
[...]
...The JAK2 V617F mutation was identified in more than 95% of PV patients and in approximately half of the patients with ET and MF but was not observed in healthy individuals (2-6)....
[...]
...As shown in Table 1, the characteristics of the studied patients are very similar to those observed in the literature (2-5), which indicates the comparability of our data and supports the assertion that the presence of the G allele is a pivotal factor in the development of cMPN in our population....
[...]
...It was observed that the JAK2 V617F mutation could occur in a homozygous or heterozygous fashion in the affected hematopoietic cells (2-5)....
[...]
843 citations
"Evaluation of the association betwe..." refers background or result in this paper
...The JAK2 V617F mutation was identified in more than 95% of PV patients and in approximately half of the patients with ET and MF but was not observed in healthy individuals (2-6)....
[...]
...As shown in Table 1, the characteristics of the studied patients are very similar to those observed in the literature (2-5), which indicates the comparability of our data and supports the assertion that the presence of the G allele is a pivotal factor in the development of cMPN in our population....
[...]
...Homozygosity frequently occurs for a specific allele through duplication of the mutated allele and consequent loss of the non-mutated allele (2)....
[...]
...It was observed that the JAK2 V617F mutation could occur in a homozygous or heterozygous fashion in the affected hematopoietic cells (2-5)....
[...]