Evaluation of the renal toxicity of heme proteins and their derivatives: a role in the genesis of acute tubule necrosis.
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Cites background from "Evaluation of the renal toxicity of..."
...Cortical ischemia and decreased glomerular filtration are also injurious, and when these conditions are combined with hypovolemia, oliguric renal failure can result [70, 71]....
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References
11,349 citations
"Evaluation of the renal toxicity of..." refers background or methods in this paper
...In the studies performed to determine the type of inhibition produced by ferrihemate, the "active" transport of hippurate was studied and the data were plotted against the hippurate concentration in the media in the manner of Lineweaver and Burk (33)....
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...B. Lineweaver-Burk plot of hippuric acid (0.9 m~) inhibition as a function of p-aminohippurate concentration. determine whether the inhibition from ferrihemate could be overcome....
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...A. Lineweaver-Burk plot of ferrihemate (40 mg/100 ml) inhibition as a function of hippurate concentration....
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...When hippurate uptake is studied in the presence of ferrihemate and a known competitive inhibitor, the Lineweaver-Burk plots of the kinetics are not similar for the two substances....
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...6 A the plot for "active" hippurate transport in the presence of ferrihemate was typical of noncompetit ive inhibit ion (33)....
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794 citations
"Evaluation of the renal toxicity of..." refers background in this paper
...In many clinical settings acute tubule necrosis is temporally related to breakdown of blood or destruction of tissue (1-6)....
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524 citations
"Evaluation of the renal toxicity of..." refers background in this paper
...Suggestions made include the following: (a) heine proteins form casts tha t plug tubules and damage cells (13-17); (b) heme proteins either cause or are associated with decreased renal blood flow, and the resultant ischemia leads to acute tubule necrosis (18, 19); and (c) heme proteins or some breakdown products directly injure tubules (12, 13, 20, 21)....
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425 citations
"Evaluation of the renal toxicity of..." refers methods in this paper
...The medium was a bicarbonate-buffered Ringer's solution (28)....
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401 citations
"Evaluation of the renal toxicity of..." refers background in this paper
...0 ml of Cross and Taggart's medium (26), with a final pH of 7....
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