Open AccessJournal Article
Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B) the summary report of the 6^ collaborative study by CSGMT/JEMS MMS. Collaborative study of the Micronucleus Group Test
Reads0
Chats0
TLDR
Structural-activity relationship analysis suggested that the micronucleus assay is more sensitive to the genetic toxicity of some classes of chemicals than to those carcinogens with stronger evidence human carcinogenicity.About:
This article is published in Mutation Research.The article was published on 1997-01-01 and is currently open access. It has received 268 citations till now. The article focuses on the topics: Micronucleus test & Micronucleus.read more
Citations
More filters
Journal ArticleDOI
The comet assay with 8 mouse organs: results with 39 currently used food additives.
Yu F. Sasaki,Satomi Kawaguchi,Asako Kamaya,Miyuki Ohshita,Kazumi Kabasawa,Kayoko Iwama,Kazuyuki Taniguchi,Shuji Tsuda +7 more
TL;DR: Of all the additives, dyes were the most genotoxic and induced DNA damage in the colon at close to the acceptable daily intakes (ADIs), and more extensive assessment of food additives in current use is warranted.
Journal ArticleDOI
Postulated carbon tetrachloride mode of action: a review.
TL;DR: Doses that do not cause sustained cytotoxicity and regenerative cell proliferation would subsequently be protective of liver tumors if this is the primary mode of action, according to a body of scientific evidence.
Journal ArticleDOI
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: III. Appropriate follow-up testing in vivo
David Kirkland,Günter Speit +1 more
TL;DR: The published in vivo UDS, TG and Comet-assay results for 67 carcinogens that were negative or equivocal in the micronucleus test suggest that they both should play a more prominent role in regulatory testing strategies than the UDS test.
References
More filters
Journal ArticleDOI
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs vol. 1 to 42. Supplement 7. 440 Seiten. International Agency for Research on Cancer, Lyon 1987. Preis: 65, – s.Fr
Journal ArticleDOI
Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.
Raymond W. Tennant,Barry H. Margolin,Michael D. Shelby,Errol Zeiger,Joseph K. Haseman,Judson W. Spalding,William J. Caspary,Michael A. Resnick,Stanley Stasiewicz,Beth Anderson,Robert Minor +10 more
TL;DR: Four widely used in vitro assays for genetic toxicity were evaluated for their ability to predict the carcinogenicity of selected chemicals in rodents, indicating that chemicals positive in one in vitro assay tended to be positive in the other in vitro Assays.
Journal ArticleDOI
Salmonella mutagenicity test results for 250 chemicals
TL;DR: This publication is a presentation of Salmonella testing results on 250 coded chemicals, encompassing 370 tests, designed both to summarize the results in the text and to present the data so that the reader has the opportunity of performing an independent evaluation of the data.
Journal ArticleDOI
Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP.
John Ashby,Raymond W. Tennant +1 more
TL;DR: There was a high correlation between structural alerts to DNA reactivity and mutagenicity, but the correlation of either property with carcinogenicity was low, and most of the rodent carcinogens were among the structurally alerting chemicals.
Journal ArticleDOI
Mutagenicities of N-nitrosamines on Salmonella.
TL;DR: The mutagenic activities of 11 N-nitrosamines were tested using Salmonella typhimurium TA100 and TA98 with a drug-activating system from the rat liver, whereas N,N-diphenylnitrosamine, a non-carcinogen, was not Mutagenic.