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Journal ArticleDOI

Evidence for a histocompatibility system in swine (SL-A).

M. Vaiman, Renard C, P Lafage, J. Ameteau, P Nizza 
01 Aug 1970-Transplantation (Transplantation)-Vol. 10, Iss: 2, pp 155-164
TL;DR: Evidence of a lymphocyte antigen system behaving as a histocompatibility system was brought out by a significant lengthening of the survival of skin grafts in the case of compatible siblings.
Abstract: SUMMARY Lymphocytotoxic isoantibodies were developed in swine by skin grafts. Seventy swine distributed into several families were tested by the sera. In each family, the parents' characters determined by these sera were transmitted to the piglets according to Mendelian laws.Evidence of a lymphocyte antigen system behaving as a histocompatibility system was brought out by a significant lengthening of the survival of skin grafts in the case of compatible siblings.
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12 Feb 2012
TL;DR: One that the authors will refer to break the boredom in reading is choosing the major histocompatibility system in man and animals as the reading material.
Abstract: Introducing a new hobby for other people may inspire them to join with you. Reading, as one of mutual hobby, is considered as the very easy hobby to do. But, many people are not interested in this hobby. Why? Boring is the reason of why. However, this feel actually can deal with the book and time of you reading. Yeah, one that we will refer to break the boredom in reading is choosing the major histocompatibility system in man and animals as the reading material.

174 citations

Journal ArticleDOI
TL;DR: A review of the lymphocyte stimulation test in veterinary immunology is given, with the main emphasis on technical aspects and possible applications of the test.

125 citations

Journal ArticleDOI
TL;DR: The amino acid alignment of the variable domains of 33 SLA classical class I chains, and 62 DRβ and 20 DQβ chains confirmed the exceptionally polymorphic pattern of these polypeptides, which seems more marked in DRB than DQB genes.
Abstract: In swine, the major histocompatibility complex (Mhc) or swine leukocyte antigen (SLA) is located on chromosome 7 and divided by the centromere. Thus, the telomeric class I and more centromeric class III regions are located on the p arm and the class II region is located on the q arm. The SLA region spans about 2 Mb, in which more than 70 genes have so far been characterized. Despite its division by the centromere, the spatial relationships between the genes in the class II and class III regions, and between the well-conserved non-class I genes of the class I region, are similar to those found in the human HLA complex. On the other hand, no orthologous relationships have been found between the Mhc class I genes in man and swine. In swine, the 12 SLA class I sequences constitute two distinct clusters. One cluster comprises six classical class I-related sequences, while the other comprises five class I-distantly related sequences including two swine homologous genes of the HLA Mhc class I chain-related gene (MIC) sequence family. The number of functional SLA classical class I genes, as defined by serology, probably varies from one to four, depending on the haplotype. Some of the SLA class I-distantly related sequences are clearly transcribed. As regards the SLA class II genes, some of them clearly code for at least one functional SLA-DR and one SLA-DQ heterodimer product, but none code for any DP product. The amino acid alignment of the variable domains of 33 SLA classical class I chains, and 62 DR beta and 20 DQ beta chains confirmed the exceptionally polymorphic pattern of these polypeptides. Among the class II genes, the genes are either monomorphic, like the DRA gene, or oligomorphic, like the DQA genes. In contrast, the DRB and DQB genes display considerable polymorphism, which seems more marked in DRB than DQB genes.

112 citations

Journal ArticleDOI
TL;DR: Lymphocytotoxic sera have been produced in forty‐seven cattle following skin grafting or lymphocyte immunization between dam‐offspring pairs and from these sera seventy antilymphocyte reagents have beenproduced.
Abstract: SUMMARY Lymphocytotoxic sera have been produced in forty-seven cattle following skin grafting or lymphocyte immunization between dam-offspring pairs. From these sera seventy antilymphocyte reagents have been produced. Seven of the sera were operationally monospecific without absorption, thirty-seven others were made operationally monospecific and twenty-six partially purified by absorption with lymphocytes. Thirty-five of these sera were used in France and an additional thirty-five were used in Scotland. The inheritance of the antigenic factors detected by these sera has been studied in 480 cattle families and the evidence is consistent with the hypothesis that at least seventeen of the factors are inherited in a simple Mendelian fashion. Fourteen of these factors show evidence of linkage with at least one other factor and are likely to be controlled by a limited number of closely linked loci. It is suggested that these loci should be identified as the BLA region.

110 citations

Journal ArticleDOI
TL;DR: It is suggested that genetic engineering methods may allow the simultaneous improvement of disease resistance and production traits in domestic animals and genes of the MHC will be especially good candidates for genetic engineering experiments to improve domestic species.
Abstract: Disease resistance and immune responsiveness have been traits generally ignored by animal breeders. Recent advances in immunology and molecular biology have opened new avenues towards our understanding of genetic control of these traits. The major histocompatibility gene complex (MHC) appears to play a central role in all immune functions and disease resistance. The need to understand the relationship between immune responsiveness, disease resistance and production traits is discussed in this review. Antagonistic relationships might prevent simultaneous improvement of all of these traits by conventional breeding methods. It is suggested that genetic engineering methods may allow the simultaneous improvement of disease resistance and production traits in domestic animals. Genes of the MHC will be especially good candidates for genetic engineering experiments to improve domestic species.

94 citations