Evidence for APOBEC3B mutagenesis in multiple human cancers
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Cites background from "Evidence for APOBEC3B mutagenesis i..."
...Curiously, the APOBECs can be induced by either wild-type or mutant p53 (Menendez et al., 2017), though a clear link between p53 status and APOBEC-mediated mutagenesis has not yet been described (Burns et al., 2013; Shinmura et al., 2011)....
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..., 2017), though a clear link between p53 status and APOBEC-mediated mutagenesis has not yet been described (Burns et al., 2013; Shinmura et al., 2011)....
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Cites background from "Evidence for APOBEC3B mutagenesis i..."
...Moreover, while both exogenous mutational processes, such as smoking (10-12) and endogenous processes, such as upregulation of APOBEC cytidine deaminases (13-15), have been found to contribute to the large mutational burden in NSCLC, the temporal dynamics of these processes and their contribution to driver somatic aberrations over time remains unknown....
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...In the majority of M-seq tumors, the decreased proportion of C>A mutations was accompanied by an increase in C>T and C>G mutations at TpC sites, indicative of APOBEC cytidine deaminase activity (13-15)....
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References
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