Evidence for degradation of mRNA encoding alpha-L-iduronidase in Hurler fibroblasts with premature termination alleles.
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Cites background from "Evidence for degradation of mRNA en..."
...In studies employing general translation inhibitors (Qian et al., 1993; Lozano et al., 1994; Menon and Neufeld, 1994; Carter et al., 1995) or suppressor tRNAs (Takeshita et al., 1984; Belgrader et al., 1993), possible pleiotropic effects of these approaches complicate the interpretation of the data....
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..., 1993) and (iv) by inhibiting global translation (Qian et al., 1993; Lozano et al., 1994; Menon and Neufeld, 1994; Carter et al., 1995), or (v) by alterating the structure of the 5 -untranslated region (5 -UTR) of a PTC-containing mRNA to inhibit translation in cis (Belgrader et al....
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...…suppressor tRNAs (Takeshita et al., 1984; Belgrader et al., 1993) and (iv) by inhibiting global translation (Qian et al., 1993; Lozano et al., 1994; Menon and Neufeld, 1994; Carter et al., 1995), or (v) by alterating the structure of the 5 -untranslated region (5 -UTR) of a PTC-containing mRNA to…...
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...In studies employing general translation inhibitors (Qian et al., 1993; Lozano et al., 1994; Menon and Neufeld, 1994; Carter et al., 1995) or suppressor tRNAs (Takeshita et al....
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