Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line
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...mutations [6,7,8,10,11,12,13], suggesting that other unknown...
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References
10,879 citations
"Evidence for efficient phosphorylat..." refers background in this paper
...It has been previously reported that gefitinib-sensitive lung tumors were found to express EGFR variants with a higher sensitivity for the drug than the wild-type receptor [29,30]....
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5,536 citations
"Evidence for efficient phosphorylat..." refers background in this paper
...These events lead to the recruitment and phosphorylation of several intracellular substrates and the subsequent transmission of extracellular signals to the nucleus via an intracellular signaling network [4,5]....
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1,627 citations
"Evidence for efficient phosphorylat..." refers background in this paper
...Following ligand binding, the EGFR is dimerized and the intracellular tyrosine kinase region is activated, causing receptor tyrosine autophosphorylation and transphosphorylation of another receptor monomer [4]....
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...These events lead to the recruitment and phosphorylation of several intracellular substrates and the subsequent transmission of extracellular signals to the nucleus via an intracellular signaling network [4,5]....
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1,559 citations
"Evidence for efficient phosphorylat..." refers background in this paper
...These proteins are distributed within endocytic organelles and are at the highest concentration in the late endosomes/lysosomes, as observed for other lysosomal glycoproteins, namely, lysosomal associated membrane protein-1 (LAMP-1) and LAMP-2 [14-17]....
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