Evidence for osteocyte regulation of bone homeostasis through RANKL expression
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Cites background from "Evidence for osteocyte regulation o..."
...Stress fractures heal by targeted remodeling of the injured site through a process of osteocyte apoptosis, which signals for repair through elevated production of receptor activator of NF‐kB ligand (RANKL),((71,72)) osteoclastic resorption to remove the damage, and then osteoblastic formation to replace resorbed bone....
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1,246 citations
Cites background from "Evidence for osteocyte regulation o..."
...2012), or those healthy osteocytes adjacent to the dying ones (Nakashima et al. 2011; Xiong et al. 2011), will begin to produce RANKL, which is important for the differentiation and activation of osteoclasts that are recruited to remove the damaged bone....
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1,160 citations
Cites background from "Evidence for osteocyte regulation o..."
...There is evidence that osteocytes act as the main source of RANKL to promote osteoclastogenesis [167, 168], although this factor has also been demonstrated to be produced by other cell types such as stromal cells [194], osteoblasts, and fibroblasts [88, 89]....
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...In the initiation phase, under the action of osteoclastogenic factors including RANKL and M-CSF, hematopoietic stem cells are recruited to specific bone surface areas and differentiate into mature osteoclasts that initiate bone resorption [167, 168]....
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...It has been suggested that osteocytes act as the main source of RANKL to promote osteoclastogenesis [166, 167]....
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1,135 citations
References
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