Journal Article•
Evidence for the existence of monoamine neurons in the central nervous system. iv. distribution of monoamine nerve terminals in the central nervous system.
About: This article is published in Acta Physiologica Scandinavica.The article was published on 1965-01-01 and is currently open access. It has received 1467 citations till now. The article focuses on the topics: Monoamine neurotransmitter & Nervous system.
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TL;DR: The ascending monoamine pathways in the rat brain are demonstrated by the pile up of fluorescent material occurring in the axons after various types of lesions, indicating a unique role for the locus coeruleus in influencing the activity of the entire brain.
Abstract: The ascending monoamine pathways in the rat brain are demonstrated by the pile up of fluorescent material occurring in the axons after various types of lesions. The anatomy of the pathways is outlined in drawings of frontal sections of the brain and the origin and termination of several pathways is determined by studying the anterograde and retrograde degeneration occurring after well localised lesions. It is possible to separate the ascending NA pathways into a dorsal and a ventral bundle of axons. The dorsal bundle innervates the cortex and the hippocampus and the ventral bundle supplies NA nerve terminals to the medulla, the pons, the mesencephalon and the diencephalon. The dorsal bundle is found to originate in the locus coeruleus. Lesions of this nucleus abolish the nerve terminals in all cortical areas and in several other areas of the brain indicating a unique role for the locus coeruleus in influencing the activity of the entire brain. The 5-HT pathways have a distribution similar to the ventral NA pathyway. The course of the nigro-striatal and the meso-limbic DA pathways is presented in detail.
3,758 citations
TL;DR: The results demonstrate a widespread occurrence of 5-HT-positive nerve terminals throughout the central nervous system and the finding that serotonin-containing neurons are present in many nuclei that also include catecholamine- containing neurons makes it necessary to reconsider the terminology of the monoaminergic cell groups.
2,362 citations
TL;DR: The distribution of serotonin-1 (5-HT1) receptors in the rat brain was studied by light microscopic quantitative autoradiography and the existence of 'selective' areas allowed a detailed pharmacological characterization of these sites to be made in a more precise manner than has been attained in membrane-binding studies.
1,866 citations
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