Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
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...108, 109 Alternatively, SARS-CoV-2 might invade the brain from the blood, if circulating particles of the virus were transported across the blood-brain barrier by binding to ACE2 receptors expressed by endothelial cells, 109 or if infected leucocytes could carry the virus with them as they migrate into the tissues as part of the immune response to infection....
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...16 could interact with ACE2 expressed in the capillary endothelium, the virus may also damage the blood-brain barrier and enter the CNS by attacking the vascular system (Baig et al., 2020)....
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Cites result from "Evidence of the COVID-19 Virus Targ..."
...Early studies evaluating mechanisms of SARS-CoV2-mediated olfactory loss have suggested neurotrophic targeting of olfactory neurons versus infection of non-neural olfactory epithelial cells.(5,6) The short-lived Covid-19-related olfactory loss found in our study favors a model in which SARS-CoV2 targets the olfactory epithelium, which can rapidly regenerate and repair after viral clearance....
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References
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"Evidence of the COVID-19 Virus Targ..." refers background in this paper
...3 The presence of the COVID-19 virus in the general circulation understandably enables it to pass into the cerebral circulation ( Figure 1A−C) where the sluggish movement of the blood within the microcirculation could be one of the factors that may facilitate the interaction of the COVID-19 virus spike protein with ACE2 expressed in the capillary endothelium....
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...3 The contribution of the neurotropic potential of SARS-CoV-2 in patients reported in the recent outbreak of COVID-19 remains to be established....
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