Evolutionary Origins of cGAS-STING Signaling
Citations
493 citations
Cites background from "Evolutionary Origins of cGAS-STING ..."
...CTT-independent responses may thus represent “primitive” forms of STING-mediated pathogen defense that may even rely on a distinct repertoire of antimicrobial effector functions not controlled by de novo gene expression (31)....
[...]
...This observation is interesting from an evolutionary perspective because the CTT is a rather recent functional element of STING, which emerged simultaneously with the IFN antiviral system (31)....
[...]
399 citations
376 citations
Cites background from "Evolutionary Origins of cGAS-STING ..."
...Of note, unlike the cGAS-STING axis, which evolved early in the metazoan lineage (Margolis et al., 2017), AIM2 is a much more recent development, in that it is only present in the mammalian class (Cridland et al., 2012)....
[...]
...Of note, unlike the cGAS-STING axis, which evolved early in the metazoan lineage (Margolis et al., 2017), AIM2 is a much more recent development, in that it is only present in the mammalian class (Cridland et al....
[...]
363 citations
303 citations
References
3,096 citations
"Evolutionary Origins of cGAS-STING ..." refers background in this paper
...The cGAS-STING Pathway in Vertebrates Cyclic GMP–AMP synthase (cGAS), and its homologues in the OAS family, are atypical among innate immune sensors in being both receptors and biosynthetic enzymes [15,16]....
[...]
2,757 citations
"Evolutionary Origins of cGAS-STING ..." refers background in this paper
...In mammalian cells, autophagy has recently been appreciated as an important innate immune pathway that appears to target and kill intracellular bacteria and viruses (reviewed in [97,98])....
[...]
...However, mice lacking most autophagy components are not impaired in their ability to control Mycobacterium tuberculosis infection [100]; indeed, many pathogens have evolved ways to counter autophagy [97,98]....
[...]
2,438 citations
"Evolutionary Origins of cGAS-STING ..." refers background in this paper
...Mice deficient in the type I IFN receptor are highly susceptible to most viral infections [6]....
[...]
2,319 citations
2,042 citations