Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
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...A similar process has, interestingly, been proposed for the inclusion of certain RNAs into ILVs (Valadi et al, 2007; Gibbings and Voinnet, 2010)....
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...growing evidence for enrichment of certain RNA species in specific vesicle types (1,17,18)....
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...EV are generally purified from medium conditioned by cells for 24 48 h, but shorter conditioning times have been used to analyze specific release of EV-associated markers after a specific stimulus: for instance, surface receptormediated stimulation (214,215) or fMLP, PMA or calcium ionophore treatment for 15 60 min (1,216,217)....
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..., 2009; Taylor and Gercel-Taylor, 2008), peripheral blood cells (Hunter et al., 2008; Valadi et al., 2007), endothelial progenitor cells (Deregibus et al....
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...More importantly, these microvesicular RNA could be transferred to other cells and translated in the recipient cells (Deregibus et al., 2007; Ratajczak et al., 2006; Valadi et al., 2007)....
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...Several tumor cell types (Rosell et al., 2009; Taylor and Gercel-Taylor, 2008), peripheral blood cells (Hunter et al., 2008; Valadi et al., 2007), endothelial progenitor cells (Deregibus et al., 2007), and embryonic stem cells (Ratajczak et al., 2006) have been shown to secrete RNA-containing…...
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...Hypothetically, the 121 miRNAs that we have found in the mast cell exosomes may interfere with 24,000 mRNAs as it has been suggested that each species may interact with up to 200 mRNA...
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...Many cells have the capacity to release exosomes, including reticulocyte...
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