Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
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1,809 citations
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...and post-translational regulation of target mRNAs (3)....
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...EVs have been shown to transfer functional mRNA and miRNA from mouse to human mast cells where mouse proteins were identified in the recipient human cells (3)....
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1,751 citations
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Cites background from "Exosome-mediated transfer of mRNAs ..."
...Exosomes may horizontally transfer mRNA and miRNA [18]....
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...diseases [18]: eMVs may contribute to vascular injury and they are capable of inducing endothelial cell activation, impairing vasorelaxation [154], and promoting arterial...
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1,712 citations
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...Recently, it has been suggested that extracellular miRNA entrapped in exosomes to be involved in intercellular communication (12,14,15)....
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...To further confirm the hypothesis of exosome-free extracellular miRNA, we fractionated blood plasma and conditioned media of MCF7 cells according to well-developed methods for exosomes isolation (12,18)....
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...Although, exosomal miRNA has been hypothesized to be involved in intercellular communication (12,15) it remains unclear whether all extracellular miRNAs are associated with exosomes and whether extracellular miRNA are present in physiologically relevant amounts for cell-to-cell signaling....
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...Extracellular miRNAs have recently been detected in exosomes isolated from peripheral blood and culture media of several cell lines (12,16)....
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1,639 citations
Cites background from "Exosome-mediated transfer of mRNAs ..."
...Although protein transport by exosomes was accepted by the research community, the transport of RNA was not shown until much later — Valadi et al. 2007 [10] is the first publication to definitively show that RNA was carried in exosomes as well....
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"Exosome-mediated transfer of mRNAs ..." refers background in this paper
...Hypothetically, the 121 miRNAs that we have found in the mast cell exosomes may interfere with 24,000 mRNAs as it has been suggested that each species may interact with up to 200 mRNA...
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2,978 citations
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"Exosome-mediated transfer of mRNAs ..." refers background in this paper
...Many cells have the capacity to release exosomes, including reticulocyte...
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1,464 citations