Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
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...Exosomes are 50- to 90-nm (24), membrane-bound particles that have been reported to be abundant in plasma (25) and that have recently been shown (in cell culture studies) to contain miRNAs (26)....
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6,141 citations
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...A major breakthrough was the demonstration that the cargo of EVs included both mRNA and miRNA and that EVassociated mRNAs could be translated into proteins by target cells (Ratajczak et al., 2006; Valadi et al., 2007)....
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...Many RNAs that were isolated with EVs were found to be enriched relative to the RNA profiles of the originating cells (Ratajczak et al., 2006; Valadi et al., 2007; Skog et al., 2008; Nolte-’t Hoen et al., 2012a), indicating that RNA molecules are selectively incorporated into EVs....
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...It has been shown that microvesicles can transfer some of their contents to other cell type...
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"Exosome-mediated transfer of mRNAs ..." refers background in this paper
...Alternatively, exosomes could putatively attach or fuse with the target-cell membrane, delivering exosomal surface proteins and perhaps cytoplasm to the recipient cel...
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264 citations
"Exosome-mediated transfer of mRNAs ..." refers methods in this paper
...MC/9 cells (ATCC, Manassas, VA), the human mast cell line HMC-1 (J, Butterfield, Mayo Clinic, /rochester, MN) and bone marrow mast cells (BMMC) were prepared and cultured as described by ATC...
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259 citations
"Exosome-mediated transfer of mRNAs ..." refers background in this paper
...Two of the best studied miRNAs are lin-4 and let-7 , which are involved in early ( lin-4 ) and late ( let-7 ) developmental timin...
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225 citations
"Exosome-mediated transfer of mRNAs ..." refers background in this paper
...Recently, several groups have shown that circular membrane fragments called microvesicles also may be involved in cell–cell communication, and may contain mRN...
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