Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity
Citations
3,715 citations
Cites background from "Exosomes mediate the cell-to-cell t..."
...For example, IFNa-stimulated human macrophages shed exosomes that deliver antiviral mediators, including the single-stranded DNA cytidine deaminase APOBEC3G (apolipoprotein BmRNA editing enzyme, catalytic polypeptidelike 3G), protecting human hepatocytes from HBV (hepatitis B virus) infection (106)....
[...]
2,207 citations
690 citations
Cites background from "Exosomes mediate the cell-to-cell t..."
...Exosomes released from interferon-α (IFN-α)treated macrophages or liver sinusoidal cells delivered antiviral RNAs and proteins to hepatocytes and reduced replication of hepatitis B virus in a hepatitis B model (Li et al., 2013a)....
[...]
...Human umbilical cordMSC-derived EVswere protective in models of acute renal injury (Bruno et al., 2009) and liver fibrosis (Li et al., 2013b)....
[...]
632 citations
Cites background from "Exosomes mediate the cell-to-cell t..."
...Exosomes can transfer viral RNA from infected cells to trigger an interferon response in immune cells, presumably through TLRs, to enhance viral suppression (Dreux et al., 2012; Li et al., 2013b)....
[...]
...Thus, our results suggest that noncoding RNA found in exosomes and similar microvesicles (Balaj et al., 2011; Li et al., 2013a) may coax antiviral responses to influence treatment resistance, potentially adding to the increasing evidence that atypical RNA transcripts can contribute to human disease....
[...]
626 citations
Cites background from "Exosomes mediate the cell-to-cell t..."
...Many studies have demonstrated that exosomes can play significant roles in the treatment of many diseases, including cancer [137], cardiovascular diseases [138, 139], neurodegenerative diseases [61], tissue injury [140], and pathogenic infections [141]....
[...]
References
10,484 citations
4,492 citations
4,118 citations
3,441 citations
2,818 citations