Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis.
Citations
265 citations
190 citations
129 citations
Cites background from "Exosomes secreted by cardiomyocytes..."
...It has been shown that ischemic EVs confer protection against oxidative-induced lesion, promote proliferation and sprouting of ECs and stimulate cardiac angiogenesis [197]....
[...]
98 citations
Cites background from "Exosomes secreted by cardiomyocytes..."
...Importantly, HPC enhanced the benefit of CMs-exos in an animal myocardial infarction model and led to an increased proangiogenic effect of exosomes [16]....
[...]
...Recently, exosomes were found to be released from CMs obtained under ischemic conditions and to promote angiogenesis [16]....
[...]
92 citations
References
6,181 citations
4,492 citations
"Exosomes secreted by cardiomyocytes..." refers methods in this paper
...To evaluate if our isolation protocol excludes large protein aggregates or proteins nonspecifically associated with vesicles, we performed an extra purification step using a sucrose.(18) The presence of the exosomal marker CD63 mainly in the sucrose gradient (Supplementary Figure (SF) 1A), and similar NTA profiles of vesicles obtained with either purification method (SF1B), confirm that the ultracentrifugation procedure is appropriate to isolate...
[...]
4,441 citations
"Exosomes secreted by cardiomyocytes..." refers background in this paper
...Angiogenesis, which is the formation of new blood vessels formation from pre-existing vasculature, is a highly controlled mechanism that involves the local breakdown and reorganization of the extracellular matrix (ECM), endothelial cells (ECs) sprouting, migration and adhesion junctions remodelling.(5) It has been shown that signals emitted...
[...]
3,959 citations
3,321 citations
"Exosomes secreted by cardiomyocytes..." refers background in this paper
...mediate intercellular communication under normal and pathological conditions by shuttling a wide range of functional lipids, proteins, mRNAs, and microRNAs (miRs).(9) It has been reported that exosomes play an important role in modulating angiogenesis, in different organs, including the heart....
[...]