Expected survival of cancer patients and myeloma undergoing bisphosphonates or denosumab. Potential impact on diagnosis and management of Osteonecrosis of Jaws (ONJ)
Vittorio Fusco,Marco Cabras,Alessio Gambino,Massimo Di Maio,Roberto Freilone,Marco Tampellini,Incoronata Romaniello,Maria Rosa Alvaro,Gianmauro Numico,Maura Rossi,Cinzia Ortega,Marcello Tucci,Davide Ottaviani,Lucio Buffoni,Giorgio V. Scagliotti,Giorgio Vellani,Paola Varese,Mario Franchini,Claudia Galassi +18 more
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TLDR
Data support careful evaluation of short and long-term actuarial ONJ risk (versus short-term absolute risk) in the choice of antiresorptive treatment duration for bone metastatic cancer and myeloma patients and exclusion of jawbone surgery due to expected short survival in most of ONJ patients seems not warranted.Abstract:
Survival of cancer and myeloma patients after diagnosis of bone lesions is largely variable. Appropriate medical therapy together with antiresorptive treatment (bisphosphonates or denosumab) can obtain prolonged survival with adequate quality of life. Osteonecrosis of Jaws (ONJ) is not rare in patients with bone metastatic cancer and myeloma patients, occurring mostly after prolonged antiresorptive treatment. Expected survival can influence the choice of antiresorptive treatment, the perception of ONJ risk, and even the ONJ management. We reviewed survival data after start of antiresorptive treatment of 509 ONJ patients registered in a cancer network database (Rete Oncologica Piemonte-Valle d’Aosta, North-Western Italy). Main characteristics: 196 males, 313 females; median age: 68 (39-89) years. Underlying disease: breast cancer: 42.9%; myeloma: 25.3%; prostate cancer: 17.2%; lung cancer: 6.7%; renal cancer: 2.5%; other cancer types: 4.3%. Main antiresorptive treatment: zoledronic acid: 79.4%; denosumab: 5.3%; other drugs/sequences: 15.3%. Actuarial median survival (range) after the start of antiresorptive treatment was 66.0 (95% CI 57-77) months for breast cancer patients, 77.3 (95% CI 61.9-86.8) months for myeloma patients, 47.3. (95% CI 37.8-51.9) months for prostate cancer patients, 29.4 (95% CI 20.4-40.1) months for lung cancer patients, 39.4 (95% CI 20-107.3) months for renal cancer patients, 82.4 (95% CI 51.9-150.9) months for other cancer patients. Two-, three- and four-year actuarial survival rates were respectively 91.7%%, 80.2%, 67.4% for breast cancer patients, 91.4%, 83.7%, 68.9% for myeloma patients, 78.4%, 61.2%, 41.9% for prostate cancer patients; 55.8%, 32.3%, 23.5% for lung cancer patients; 61.5%, 53.8%, 46.1% for renal cancer patients; 81.8%, 77.3%, 68.1% for others cancer types. Our data support careful evaluation of short and long-term actuarial ONJ risk (versus short-term absolute risk) in the choice of antiresorptive treatment duration for bone metastatic cancer and myeloma patients. Furthermore, exclusion of jawbone surgery due to expected short survival in most of ONJ patients seems not warranted.read more
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Survival of myeloma patients receiving bisphosphonates in a "real life" experience: potential impact on risk of osteonecrosis of the jaw (onj)
Federico Monaco,Vittorio Fusco,Giulia Limberti,Antonella Fasciolo,Elisabetta Ferrero,Paola Brigo,Daniela Tartara,Anna Baraldi,Gioacchino Catania,M Ladetto +9 more
TL;DR: Expected survival of myeloma patients in a “real life” setting after the start of antiresorptive treatment is medially long in terms of years, with a large portion of patients exposed at risk of developing Osteonecrosis of the Jaw for more than 5 years.
References
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Journal ArticleDOI
American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update.
Salvatore L. Ruggiero,Thomas B. Dodson,John Fantasia,Reginald Goodday,Tara Aghaloo,Bhoomi Mehrotra,Felice O'Ryan +6 more
TL;DR: The American Association of Oral and Maxillofacial Surgeons (AAOMS) developed guidelines for medication-related osteonecrosis of the jaw (MRONJ) in 2007 and 2009 as mentioned in this paper.
Journal ArticleDOI
Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO/ASCO Clinical Practice Guideline
Noam Yarom,Noam Yarom,Charles L. Shapiro,Douglas E. Peterson,Catherine Van Poznak,Kari Bohlke,Salvatore L. Ruggiero,Salvatore L. Ruggiero,Cesar A. Migliorati,Aliya Khan,Archie Morrison,Archie Morrison,Holly Anderson,Barbara A. Murphy,Devena E. Alston-Johnson,Rui Amaral Mendes,Beth M. Beadle,Siri Beier Jensen,Deborah P. Saunders +18 more
TL;DR: In this paper, the authors provide guidance regarding best practices in the prevention and management of medication-related osteonecrosis of the jaw (MRONJ) in patients with cancer.
Journal ArticleDOI
Medication-related osteonecrosis of the jaw: Prevention, diagnosis and management in patients with cancer and bone metastases.
TL;DR: A multidisciplinary, pragmatic approach to MRONJ should be adopted, prioritizing patient's quality of life and management of their skeletal malignant disease.
Journal ArticleDOI
Bortezomib plus rituximab alone in patients with relapsed, rituximab-naive or rituximab-sensitive, follicular lymphoma: a randomised phase 3 Trial.
B. Coiffier,Ea Osmanov,Xiaonan Hong,Adriana Scheliga,Jiří Mayer,Fritz Offner,Simon Rule,Adriana Teixeira,Jan Walewski,S. de Vos,Michael Crump,Ofer Shpilberg,DL Esseltine,Eugene Zhu,Christopher Enny,Panteli Theocharous,H. Van De Velde,Ya Elsayed,Pl Zinzani,Lym study investigators,Marina. Liberati Anna +20 more
Journal ArticleDOI
Long-term outcomes of surgical resection of the jaws in cancer patients with bisphosphonate-related osteonecrosis
Alberto Bedogni,Giorgia Saia,Giordana Bettini,A. Tronchet,Andrea Totola,Giorgio Bedogni,Giuseppe Ferronato,Pier Francesco Nocini,Stella Blandamura +8 more
TL;DR: Surgical resection of BRONJ was highly effective, with few post-operative complications and were not associated with long-term mortality.