Experimental vaccines against potentially pandemic and highly pathogenic avian influenza viruses
Citations
193 citations
47 citations
Cites background from "Experimental vaccines against poten..."
...This would likely limit the use and/or efficacy of poxvirus-vectored influenza virus vaccines for regular and seasonal use [13]....
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...availability of current inactivated vaccines, live-attenuated and virus-vectored vaccines are still considered one of the best options for the induction of broad and efficacious immunity to the influenza virus [13]....
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43 citations
Cites background from "Experimental vaccines against poten..."
...Measles virus – HIV infection – Measles/HIV combination – West Nile virus infection – RNA virus, unable to integrate in host genome – Well known homologous vaccine – Can induce both mucosal and systemic immunity – Pre-existing immunity – Moderate foreign antigenic load [9,28,38]...
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...– Gradient gene expression – Instable genome [38]...
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...– Administration both intranasally and intramuscularly – No pre-existing immunity – No clinical safety data for use in humans available [38,47]...
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...[47] Tripp RA, Tompkins SM. Virus-vectored influenza virus vaccines....
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...[38] Mooney AJ, Tompkins SM. Experimental vaccines against potentially pandemic and highly pathogenic avian influenza viruses....
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27 citations
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References
14,532 citations
"Experimental vaccines against poten..." refers background in this paper
...Moreover, plasmid-vaccinated animals have been shown to express the DNA vaccine in dendritic cells, improving T-cell and global vaccine responses [45]....
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...Adenoviruses infect dendritic cells, among a wide range of other cells, leading to eff icient antigen presentation to the immune system [45]....
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2,557 citations
"Experimental vaccines against poten..." refers background in this paper
...DNA-based vaccines DNA-based vaccines (reviewed in [42]) in short, are bacterial plasmids containing an optimized mammalian promoter driving expression of the gene of interest [42], nucleotide sequences (cytidine phosphate guanosine, or CpG) that stimulate the innate immune system via TLR-9 (reviewed in [43]), and usually a selection marker required for production of the plasmid in bacteria....
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1,833 citations