Exploration of the platelet proteome in patients with early-stage cancer.
Siamack Sabrkhany,Marijke J.E. Kuijpers,Jaco C. Knol,Steven W.M. Olde Damink,Anne-Marie C. Dingemans,Henk M.W. Verheul,Sander R. Piersma,Thang V. Pham,Arjan W. Griffioen,Mirjam G.A. oude Egbrink,Connie R. Jimenez +10 more
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TLDR
It is demonstrated that the platelet proteome of patients with early-stage lung or head of pancreas cancer differs considerably compared to that of healthy individuals of matched sex and age and after surgical resection of the tumor.About:
This article is published in Journal of Proteomics.The article was published on 2018-04-15 and is currently open access. It has received 55 citations till now. The article focuses on the topics: Proteome & Cancer.read more
Citations
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Tumor-educated platelets.
TL;DR: This work provides further insight into TEPs, and focuses on the evaluation of biomarker types, including circulating tumor DNA, circulating tumor cells, extracellular vesicles, and tumor-educated platelets.
Journal ArticleDOI
The Role of Platelets in the Tumor-Microenvironment and the Drug Resistance of Cancer Cells
TL;DR: A review of recent investigations on the role of platelets in the tumor-microenvironment including angiogenesis, and metastasis, as well as targeting platelets for cancer treatment, especially in drug resistance are presented.
Journal ArticleDOI
Platelet-Membrane-Camouflaged Black Phosphorus Quantum Dots Enhance Anticancer Effect Mediated by Apoptosis and Autophagy.
Yinghui Shang,Qinghai Wang,Bin Wu,Qiangqiang Zhao,Jian Li,Xueyuan Huang,Wansong Chen,Rong Gui +7 more
TL;DR: It is demonstrated that the above platform significantly enhances tumor targeting and promotes mitochondria-mediated cell apoptosis and autophagy in tumor cells.
Journal ArticleDOI
Liquid biopsies for management of pancreatic cancer.
Mohamadmahdi Samandari,María Gil Julia,Alistair Rice,Antonios Chronopoulos,Armando del Río Hernández +4 more
TL;DR: This review focuses on describing the biology of tumor‐derived materials, methods for their enrichment and detection, as well as their potential for clinical application, and the future direction of liquid biopsies.
Journal ArticleDOI
Lessons to learn from tumor-educated platelets.
TL;DR: In this paper, the authors cover the various modalities of platelet education by tumors, in addition to assessing their diagnostic potential, including direct uptake and storage of tumor-derived factors, signal-dependent changes in platelet RNA processing, and differential platelet production by tumor-educated megakaryocytes.
References
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Journal ArticleDOI
Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
Paul Shannon,Andrew Markiel,Owen Ozier,Nitin S. Baliga,Jonathan T. Wang,Daniel Ramage,Nada Amin,Benno Schwikowski,Trey Ideker +8 more
TL;DR: Several case studies of Cytoscape plug-ins are surveyed, including a search for interaction pathways correlating with changes in gene expression, a study of protein complexes involved in cellular recovery to DNA damage, inference of a combined physical/functional interaction network for Halobacterium, and an interface to detailed stochastic/kinetic gene regulatory models.
Journal ArticleDOI
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.
Jiirgen Cox,Matthias Mann +1 more
TL;DR: MaxQuant, an integrated suite of algorithms specifically developed for high-resolution, quantitative MS data, detects peaks, isotope clusters and stable amino acid isotope–labeled (SILAC) peptide pairs as three-dimensional objects in m/z, elution time and signal intensity space and achieves mass accuracy in the p.p.b. range.
Journal ArticleDOI
STRING v10: protein–protein interaction networks, integrated over the tree of life
Damian Szklarczyk,Andrea Franceschini,Stefan Wyder,Kristoffer Forslund,Davide Heller,Jaime Huerta-Cepas,Milan Simonovic,Alexander Roth,Alberto Santos,Kalliopi Tsafou,Michael Kuhn,Peer Bork,Lars Juhl Jensen,Christian von Mering +13 more
TL;DR: H hierarchical and self-consistent orthology annotations are introduced for all interacting proteins, grouping the proteins into families at various levels of phylogenetic resolution in the STRING database.
Journal ArticleDOI
BiNGO : a Cytoscape plugin to assess overrepresentation of Gene Ontology categories in Biological Networks
TL;DR: The Biological Networks Gene Ontology tool (BiNGO) is an open-source Java tool to determine whichGene Ontology terms are significantly overrepresented in a set of genes.
Journal ArticleDOI
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more
TL;DR: The ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types was evaluated and suggested that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes.
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