Journal ArticleDOI
Exploring and exploiting chemistry at the cell surface
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TLDR
The emerging field of dynamic surfaces capable of stimulating and responding to cellular activity in real time is discussed, and the most popular classes of functional molecules grafted on engineered surfaces are reviewed.Abstract:
Engineering the surface chemistry of a material so that it can interface with cells is an extraordinarily demanding task. The surface of a cell is composed of thousands of different lipids, proteins and carbohydrates, all intricately (and dynamically) arranged in three dimensions on multiple length scales. This complexity presents both a challenge and an opportunity to chemists working on bioactive interfaces. Here we discuss how some of these challenges can be met with interdisciplinary material synthesis. We also review the most popular classes of functional molecules grafted on engineered surfaces and explore some alternatives that may offer greater flexibility and specificity. Finally, we discuss the emerging field of dynamic surfaces capable of stimulating and responding to cellular activity in real time.read more
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Organic Bioelectronics: Bridging the Signaling Gap between Biology and Technology.
TL;DR: The field of organic bioelectronics is introduced, from its early breakthroughs to its current results and future challenges, and is maturing toward applications ranging from life sciences to the clinic.
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Protein-Nanoparticle Interactions
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Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles
Brian T. Luk,Che Ming Jack Hu,Ronnie H. Fang,Diana Dehaini,Cody W. Carpenter,Weiwei Gao,Liangfang Zhang +6 more
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Matrix Stiffness and Nanoscale Spatial Organization of Cell-Adhesive Ligands Direct Stem Cell Fate
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Small Bioactive Peptides for Biomaterials Design and Therapeutics
TL;DR: This review provides a convenient resource, summarizing a broad range of important sequences with great utility as a resource concerning both small peptide drugs and also novel biofunctional peptide-based materials.
References
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Journal ArticleDOI
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
TL;DR: The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed.
Journal ArticleDOI
Exploring and engineering the cell surface interface.
TL;DR: Current approaches to control cell behavior through the nanoscale engineering of materials surfaces are reviewed and implications are emerging for applications including medical implants, cell supports, and materials that can be used as instructive three-dimensional environments for tissue regeneration.
Journal ArticleDOI
Biomimetic materials for tissue engineering.
TL;DR: The surface and bulk modification of biomaterials with cell recognition molecules to design biomimetic materials for tissue engineering and recent advances for the development of biomimetics materials in bone, nerve, and cardiovascular tissue engineering are summarized.
Journal ArticleDOI
Complexity in biomaterials for tissue engineering
TL;DR: The molecular and physical information coded within the extracellular milieu is informing the development of a new generation of biomaterials for tissue engineering, and exciting developments are likely to help reconcile the clinical and commercial pressures on tissue engineering.