Journal ArticleDOI
Exploring the costs of horizontal gene transfer
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TLDR
Focusing on costs of HGT as foundations for future studies will enhance exploration at the interface between acquired regions and recipient genomes, including the process of amelioration, and enable experimental evaluation of the role of H GT in structuring genetic diversity across populations.Abstract:
Horizontal gene transfer (HGT) is one of the most important evolutionary forces within microbial populations. Although evidence for beneficial fitness effects of HGT is overwhelming, recently acquired regions often function inefficiently within new genomic backgrounds so that each transfer event has the potential to disrupt existing regulatory and physiological networks. Identifying and exploring costs is essential for guiding general discussions about the interplay between selection and HGT, as well as generating hypotheses to explain how HGT affects evolutionary potential through, for example, changing adaptive trajectories. Focusing on costs of HGT as foundations for future studies will enhance exploration at the interface between acquired regions and recipient genomes, including the process of amelioration, and enable experimental evaluation of the role of HGT in structuring genetic diversity across populations.read more
Citations
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Journal ArticleDOI
Antimicrobial resistance in ESKAPE pathogens
David M. P. De Oliveira,Brian M. Forde,Timothy J. Kidd,Patrick N A Harris,Mark A. Schembri,Scott A. Beatson,David L. Paterson,Mark J. Walker +7 more
TL;DR: The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due to treatment failure and requires a coordinated global response for antim antibiotic resistance surveillance.
Journal ArticleDOI
Environmental factors influencing the development and spread of antibiotic resistance
TL;DR: This work attempts to define the ecological and evolutionary environmental factors that contribute to resistance development and transmission and investigates under what conditions and to what extent environmental selection for resistance takes place.
Journal ArticleDOI
Functional horizontal gene transfer from bacteria to eukaryotes
Filip Husnik,John P. McCutcheon +1 more
TL;DR: This Review focuses on gene transfers from bacteria to eukaryotes, discusses how horizontally transferred genes become functional and explores what functions are endowed upon a broad diversity of eukARYotes by genes derived from bacteria.
Journal ArticleDOI
Fitness Costs of Plasmids: a Limit to Plasmid Transmission
TL;DR: The literature in the field is analyzed and the potential fitness effects produced by plasmids throughout their life cycle in the host bacterium are examined, and the various mechanisms evolved byplasmids and bacteria to minimize the cost entailed by these mobile genetic elements are explored.
Journal ArticleDOI
The genetic basis of the fitness costs of antimicrobial resistance : : a meta-analysis approach
Tom Vogwill,R. Craig MacLean +1 more
TL;DR: The study shows that the cost of antimicrobial resistance can be partially explained by its genetic basis, and highlights both the danger associated with plasmidborne resistance and the need to understand why resistance plasmids carry a relatively low cost.
References
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Journal ArticleDOI
Horizontal gene transfer in eukaryotic evolution
TL;DR: The number of well-supported cases of transfer from both prokaryotes and eukaryotes, many with significant functional implications, is now expanding rapidly and major recent trends include the important role of HGT in adaptation to certain specialized niches and the highly variable impact of H GT in different lineages.
Journal ArticleDOI
Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution
D. Allan Drummond,Claus O. Wilke +1 more
TL;DR: In this article, the authors demonstrate conserved patterns of simple covariation between sequence evolution, codon usage, and mRNA level in E. coli, yeast, worm, fly, mouse, and human that suggest that all observed trends stem largely from a unified underlying selective pressure.
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Mobility of Plasmids
Christopher Smillie,M. Pilar Garcillán-Barcia,M. Victoria Francia,Eduardo P. C. Rocha,Fernando de la Cruz +4 more
TL;DR: A computational protocol was established to identify and classify conjugation and mobilization genetic modules in 1,730 plasmids, suggesting the existence of unsuspected new relaxases in archaea and new conjugations systems in cyanobacteria and actinobacteria.
Journal ArticleDOI
Amelioration of Bacterial Genomes: Rates of Change and Exchange
TL;DR: Estimates of amelioration times indicate that the entire Escherichia coli chromosome contains more than 600 kb of horizontally transferred, protein-coding DNA, which predicts that the E. coli and Salmonella enterica lineages have each gained and lost more than 3 megabases of novel DNA since their divergence.
Journal ArticleDOI
The Molecular Diversity of Adaptive Convergence
Olivier Tenaillon,Olivier Tenaillon,Olivier Tenaillon,Alejandra Rodríguez-Verdugo,Rebecca L. Gaut,Pamela McDonald,Albert F. Bennett,Anthony D. Long,Brandon S. Gaut +8 more
TL;DR: The pervasive presence of epistasis among beneficial mutations was inferred, which shaped adaptive trajectories into at least two distinct pathways involving mutations either in the RNA polymerase complex or the termination factor rho.