Exploring the genetic basis of chronic periodontitis: a genome-wide association study
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Cites background from "Exploring the genetic basis of chro..."
...…changes, and the presence of keystone pathogens that can transform a symbiotic microbiota into a dysbiotic one (Stabholz et al., 2010; Zhou et al., 2011; Eskan et al., 2012; Hajishengallis et al., 2012; Laine et al., 2012; Divaris et al., 2013; Lindroth & Park, 2013; Hajishengallis, 2014a)....
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...response to environmental changes, and the presence of keystone pathogens that can transform a symbiotic microbiota into a dysbiotic one (Stabholz et al., 2010; Zhou et al., 2011; Eskan et al., 2012; Hajishengallis et al., 2012; Laine et al., 2012; Divaris et al., 2013; Lindroth & Park, 2013; Hajishengallis, 2014a)....
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References
26,280 citations
"Exploring the genetic basis of chro..." refers methods in this paper
...Using these SNPs, identity-by-state (IBS) allele sharing distance (DST values) was computed using PLINK (49), as such: DST ¼ IBS distance (IBS2 + 0.5 × IBS1)/(n SNP pairs)....
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...Using these SNPs, identity-by-state (IBS) allele sharing distance (DST values) was computed using PLINK (49), as such: DST 1⁄4 IBS distance (IBS2 + 0....
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...This step was implemented with PLINK, filtering SNPs that were correlated (r2 ≥ 0.1) with the index SNP (lowest P-value) in each locus and within a distance of 400 Kb....
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11,571 citations
"Exploring the genetic basis of chro..." refers methods in this paper
...We used PolyPhen-2 for the prediction of potentially damaging missense changes (54) and METAL (55) for the summarization and meta-analysis of estimates derived from the two cohorts....
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9,387 citations
"Exploring the genetic basis of chro..." refers methods in this paper
...Population stratification was further evaluated with principal component (PC) analysis using the EIGENSTRAT program (50)....
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"Exploring the genetic basis of chro..." refers background or methods in this paper
...The estimation of heritable variance (h2) in the two periodontitis traits explained by all available SNPs in the present GWAS was performed with the use of GCTA (56)....
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...(56)], among the European American participants of the Dental ARIC study (n 1⁄4 4504)...
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...The estimation of heritable variance (h(2)) in the two periodontitis traits explained by all available SNPs in the present GWAS was performed with the use of GCTA (56)....
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...GCTA is based on a two-step method, where in the first step, all available SNPs are used to estimate a genetic relationship matrix (GRM) among all study participants....
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