Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.
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...Previously, Fadok and colleagues (15) suggested that the hypothetical exposure of PS on the outer PM leaflet of apoptotic cells may be due to the failure of an outside-inside PS translocase that has been implicated in the maintenance of normal PM asymmetry in erythrocytes and platelet membranes (48, 49)....
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...No t all macrophage populations recognized apoptotic cells in a PS-dependent manner; rather, macrophages derived from the peritoneal cavity of mice (an inflammatory site) used a putative PS receptor to bind apoptotic cells, whereas bone marrow- or blood-derived macrophages used the T S P / V n R / C D 3 6 system (15, 16)....
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...Macrophages elicited from the peritoneal cavities of mice specifically recognized apoptotic cells in a manner that was inhibited by liposomes containing PS, but not by liposomes containing other aminophospholipids (15, 16)....
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...(c) O f particular relevance to this study, Fadok and colleagues (15, 16) have provided convincing evidence for the involvement of PS in the recognition of apoptotic cells by certain macrophage populations....
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...There is also evidence to suggest that phosphatidylserine (PS), which is normally almost totally confined to the inner leaflet of the plasma membrane (PM), may act as as a membrane "flag" on apoptotic cells (15-17)....
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