Expression of Extracellular Matrix Proteins Accompanies Lesion Growth in a Model of Intimal Reinjury
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Cites background from "Expression of Extracellular Matrix ..."
...The expression of Itga5 in EC is essential for the regenerative capacity of the cells following vascular injury, mainly due to its interaction with fibronectin, which represents an abundant component of the extracellular matrix (ECM) following vascular injury.(22) Indeed, the concerted interaction of integrins with ECM components is a prerequisite for the adhesion, proliferation, and migration of EC in the process of re-endothelialization....
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"Expression of Extracellular Matrix ..." refers background in this paper
...The fact that these lesions do not possess an intact endothelium would render the arterial wall permeable to plasma proteins, which would include TPA.35,36 The presence of increased PA activity at early times (1 to 7 days) after reinjury may explain why no increase in matrix accumulation was detected at the early times after reinjury but does not provide an answer as to why an increase in ECM was detected 28 days after reinjury....
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...The fact that these lesions do not possess an intact endothelium would render the arterial wall permeable to plasma proteins, which would include TPA.(35,36) The presence of increased PA activity at early times (1 to 7 days) after reinjury may explain why no increase in matrix accumulation was detected at the early times after reinjury but does not provide an answer as to why an increase in ECM was detected 28 days after reinjury....
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...The lack of concordance between activity and expression may be due to plasma-derived TPA....
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