Expression of M-twist during postimplantation development of the mouse.
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TLDR
A detailed analysis of M‐twist expression patterns from day 7 post coitum (p.c.) to day 18 p.c. indicates a more general function of the Drosophila twist gene, suggesting additional tissue specific functions.Abstract:
The murine homologue of the Drosophila twist gene has been shown to be essential for head mesenchyme formation and to act as an inhibitor of muscle differentiation. This paper presents a detailed analysis of M-twist expression patterns from day 7 post coitum (p.c.) to day 18 p.c., indicating a more general function of the M-twist gene. At day 7 p.c., M-twist is expressed in the mesoderm outside the primitive streak. Later M-twist message is predominantly found in the somites, the head mesenchyme, the branchial arches, the limbs, and in the mesenchyme underneath the epidermis. Beginning at day 8 p.c., M-twist is mainly expressed in undifferentiated cells committed to muscle and cartilage development: this expression is consistent with a suggested role of M-twist in inhibiting overt muscle and cartilage differentiation. However, during organogenesis, M-twist is expressed in several areas of mesenchyme-epithelia interactions, suggesting additional tissue specific functions.read more
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Mutations in TWIST , a basic helix–loop–helix transcription factor, in Saethre-Chotzen syndrome
Timothy D. Howard,William A. Paznekas,Eric D. Green,Lydia C. Chiang,Nancy Ma,Rosa Luna,Costanza Garcia Delgado,Mario Gonzalez-Ramos,Antoine D. Kline,Ethylin Wang Jabs +9 more
TL;DR: The emerging cascade of molecular components involved in craniofacial and limb development now includes TWIST, which may function as an upstream regulator of FGFRs, another gene family implicated in human craniosynostosis.
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Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling.
TL;DR: These factors provide a mechanism whereby cadherin loss and increased Wnt signaling induce epithelial-mesenchymal transition in both carcinomas and development.
Journal ArticleDOI
twist is a potential oncogene that inhibits apoptosis
Roberta Maestro,Angelo Paolo Dei Tos,Yasuo Hamamori,Svetlana Krasnokutsky,Vittorio Sartorelli,Larry Kedes,Claudio Doglioni,David Beach,Gregory J. Hannon +8 more
TL;DR: Twin may play multiple roles in the formation of rhabdomyosarcomas, halting terminal differentiation, inhibiting apoptosis, and interfering with the p53 tumor-suppressor pathway.
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Substrate stiffness affects early differentiation events in embryonic stem cells.
Nicholas D. Evans,Caterina Minelli,Eileen Gentleman,Vanessa L.S. LaPointe,Sameer N. Patankar,Maria Kallivretaki,Xinyong Chen,Clive J. Roberts,Molly M. Stevens +8 more
TL;DR: A fundamental role for mechanosensing in mammalian development is suggested and the mechanical environment should be taken into consideration when engineering implantable scaffolds or when producing therapeutically relevant cell populations in vitro is illustrated.
Journal ArticleDOI
Integration of FGF and TWIST in calvarial bone and suture development.
David P. Rice,Thomas Åberg,Yan-Shun Chan,Zequn Tang,Päivi Kettunen,Leila Pakarinen,Robert E. Maxson,Irma Thesleff +7 more
TL;DR: A model of osteoblast differentiation integrating Twist and FGF in the same pathway, in which FGF acts both at early and late stages is proposed, which may lead to craniosynostosis.
References
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TL;DR: It is proposed that HLH proteins lacking a basic region may negatively regulate other HLHprotein through the formation of nonfunctional heterodimeric complexes.
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HNF-3β is essential for node and notochord formation in mouse development
TL;DR: HNF -3β Is not required for the development of definitive endoderm cells, but foregut morphogenesis is severely affected in HNF-3β −/− embryos, and patterning along the anterior-posterior axis was surprisingly little affected.
Journal ArticleDOI
Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death.
TL;DR: The results suggest that while Myf-5 plays a crucial role in the formation of lateral sclerotome derivatives, My f-5 is dispensable for the development of skeletal muscle, perhaps because other members of the myogenic HLH family substitute for MyF-5 activity.