Facile synthesis of block copolypeptides of defined architecture
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...GLP-1 (22-36) Interleukin-8 (35-72) I n t e r l e u k i n 8 ( 1 3 3 )RNase A (11 –124) G L P 1 ( 2 2 3 6 ) I n t e r l e u k i n 8 ( 3 5 7 2 ) Interleukin-8 (1-33) RNase A (110–111)...
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...GLP-1 (22-36) Interleukin-8 (35-72) I n t e r l e u k i n 8 ( 1 3 3 ) 1 (2 –36) G L P 1 ( 2 2 3 6 ) I n t e r l e u k i n 8 ( 3 5 7 2 ) Interleukin-8 (1-33) GLP1 (7–21) G L P 1 ( 2 2 3 6 ) I n t e r l e u k i n 8 ( 3 5 7 2 ) Interleukin-8 (1-33) GLP1 (7–21) G L P 1 ( 2 2 3 6 ) I n t e r l e u k i n 8 ( 3 5 7 2 ) Interleukin-8 (1-33) RNase A (110–111) GLP-1 (22-36) Interleukin-8 (35-72) I n t e r l e u k i n 8 ( 1 3 3 )RNase A (11 –124)...
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...Cleavage/deprotection O H N (solid support) Ribonuclease A, residues 110–124 Interleukin-8 (1-33) Interleukin-8 (35-72) GLP-1 (22-36) Interleukin-8 (1-33)Interleukin 8 (1–33) Interleukin 8 (35–72) Interleukin-8 (35-72)Interleukin-8 (1-33) Interleukin 8 (35–72) Interleukin-8 (35-72) Interleukin-8 (1-33)Interleukin 8 (1–33) Interleukin-8 (35-72)Interleukin-8 (1-33) 1 (2 –36) GLP-1 (22-36)Interleukin-8 (35-72)Interleukin-8 (1-33) 1 (2 –36) GLP-1 (22-36) Interleukin-8 (35-72) Interleukin-8 (1-33)GLP1 (7–21) GLP-1 (22-36) Interleukin-8 (35-72) Interleukin-8 (1-33)GLP1 (7–21) GLP-1 (22-36) Interleukin-8 (35-72) Interleukin-8 (1-33)RNase A (110–111) GLP-1 (22-36)Interleukin-8 (35-72)Interleukin-8 (1-33)RNase A (11 –124) GLP-1 (22-36)Interleukin-8 (35-72)Interleukin-8 (1-33)RNase A (11 –124) GLP-1 (22-36) Interleukin-8 (35-72) Interleukin-8 (1-33)RNase A (110–111) Interleukin-8 (35-72)Interleukin-8 (1-33) MUC2 rep at u it Interleukin-8 (35-72)Interleukin-8 (1-33) MUC2 rep at u it Interleukin-8 (35-72) Interleukin-8 (1-33)MUC2 repeat unit Interleukin-8 (35-72) Interleukin-8 (1-33)MUC2 repeat unit • Figure 6 | Methods for chemoselective amide forming ligation for peptides, proteins and glycopeptides. a, Synthesis of human interleukin 8 by native chemical ligation (NCL) of a C-terminal peptide thioester and an N-terminal cysteine residue to give a native amide linkage. b, Traceless Staudinger ligation between a C-terminal phosphinothioester and an azide for the synthesis of a fragment of RNase A. c, Decarboxylative amide ligation between a C-terminal peptide a-ketoacid and an N-terminal hydroxylamine to form a native amide bond....
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...Interleukin-8 (35-72) I n t e r l e u k i n 8 ( 1 3 3 ) Interleukin 8 (35–72) I n t e r l e u k i n 8 ( 3 5 7 2 ) Interleukin-8 (1-33) Interleukin 8 (1–33)...
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...Interleukin-8 (35-72) I n t e r l e u k i n 8 ( 1 3 3 ) 1 (2 –36)...
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References
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"Facile synthesis of block copolypep..." refers background in this paper
...The use of components with regular structures, such as rigid-rod polymers, can increase the extent of spatial organization in self-assembling material...
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698 citations
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"Facile synthesis of block copolypep..." refers background in this paper
...Proteins form hierarchically organized structures in which the fundamental motifs are generally α-helical coils and β-sheet...
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